(Q35198262)

7 August 2017

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title

When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly (English)

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7 August 2017

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1 reference

Klaus Turnheim

1

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7 August 2017

publication date

1 August 2003

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7 August 2017

published in

Experimental Gerontology

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7 August 2017

volume

38

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7 August 2017

issue

8

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7 August 2017

page(s)

843-853

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Drugs and falls: rethinking the approach to medication risk in older adults

7 August 2017

cites work

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7 January 2021

The management of chronic pain in older persons: AGS Panel on Chronic Pain in Older Persons. American Geriatrics Society

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7 January 2021

American College of Cardiology/American Heart Association Chronic Heart Failure Evaluation and Management guidelines: relevance to the geriatric practice

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7 January 2021

Survival benefits of angiotensin-converting enzyme inhibitors in older heart failure patients with perceived contraindications

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7 January 2021

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical pharmacokinetics of fluoxetine

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Protective effect of anti-hypertensive treatment on cognitive function in essential hypertension: analysis of published clinical data

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7 January 2021

Differential kinetics of phenytoin in elderly patients.

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7 January 2021

Explicit criteria for determining potentially inappropriate medication use by the elderly. An update

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

An evidence-based evaluation of the gastrointestinal safety of coxibs

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Is there an antiaging medicine?

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Overmedication of the low-weight elderly

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

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7 January 2021

The Colorado thyroid disease prevalence study

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7 January 2021

Hormone replacement therapy in relation to breast cancer

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Prediction of creatinine clearance from serum creatinine

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Age and propranolol stereoselective disposition in humans

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Demographics, assessment and management of pain in the elderly

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Benefits of treating hypertension in the elderly: should age affect treatment decisions?

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Felodipine Clinical Pharmacokinetics

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Hepatic drug metabolism and aging

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Central nervous system-active medications and risk for falls in older women

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Cyclosporin clinical pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Effects of renin-angiotensin system blockade in the aging kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Structural modifications of proteins during aging

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Age-associated changes in central nervous system glycerolipid composition and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Steady-state pharmacokinetics of citalopram in young and elderly subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Differential pharmacokinetics of digoxin in elderly patients

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Cyclooxygenase-2 inhibition and renal physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

[Anticonvulsant treatment in old age--principles and differential indications]

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The quest to reverse time's toll

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Oral anticoagulants. Pharmacologic issues for use in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6--an evaluation with the nonparametric maximum likelihood method

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The underuse of therapy in the secondary prevention of hip fractures

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical pharmacokinetics of ropinirole

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

1 reference

7 January 2021

Neuropharmacology in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical pharmacokinetics of mexiletine

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Physiological changes due to age. Pharmacodynamic changes of drug action and implications for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Hormone replacement therapy and breast carcinoma risk in Hispanic and non-Hispanic women

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Interindividual variability in sensitivity to warfarin--Nature or nurture?

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Contribution of adverse drug reactions to hospital admission of older patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pharmacokinetics of irbesartan are not altered in special populations

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Caloric restriction and aging: an update

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Age-dependent changes of the kidneys: pharmacological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Signal transduction in cellular senescence.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Position statement on human aging

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Change in creatinine clearance with advancing age.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Assessment of adherence to renal dosing guidelines in long-term care facilities

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

[Use of drugs in residents of homes for the elderly and nursing homes in comparison with patients in ambulatory care or without need of care]

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical implications of physiological changes in the aging heart

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Multidrug resistance in oncology: diagnostic and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Age-dependent differences in the anticoagulant effect of phenprocoumon in patients after heart valve surgery

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Psychotropic drug use in nursing homes--diagnostic indications and variations between institutions

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical pharmacokinetics of imipramine and desipramine

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Inappropriate medication prescribing in residential care/assisted living facilities

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Inappropriate drug prescriptions for elderly residents of board and care facilities

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pharmacodynamics: changes in homeostatic mechanisms, receptor and target organ sensitivity in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Mechanisms of photodamage of the skin and its functional consequences for skin ageing

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Pitfalls of pharmacokinetic dosage guidelines in renal insufficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Drug dosage in the elderly. Is it rational?

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Drug-induced orthostatic hypotension in the elderly: avoiding its onset

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Aging and pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Frailty and the older man.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Influence of diet and nutritional status on drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The aging immune system: primary and secondary alterations of immune reactivity in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

A Darwinian-evolutionary concept of age-related diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

How well are community-living people treated for osteoporosis after hip fracture?

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The effect of age on pharmacokinetics of antiepileptic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

Epigenetic aspects of cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

The potential advantages of a modern antihypertensive therapy in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900133-5

7 January 2021

10.1016/S0531-5565(03)00133-5

Identifiers

DOI

1 reference

7 August 2017

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