(Q34531655)

2 August 2017

Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib (English)

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2 August 2017

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Ute Hofmann

5

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author name string

Stefanie S Brenner

1

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2 August 2017

Charlotte Herrlinger

2

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2 August 2017

Karin Dilger

3

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2 August 2017

Thomas E Mürdter

4

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2 August 2017

Claudia Marx

6

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2 August 2017

Ulrich Klotz

7

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2 August 2017

1 January 2003

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Clinical Pharmacokinetics

2 August 2017

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2 August 2017

42

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2 August 2017

3

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2 August 2017

283-292

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https://scigraph.springernature.com/pub.10.2165/00003088-200342030-00003

2 August 2017

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cites work

Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.

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12 December 2020

Metabolism and excretion of [(14)C]celecoxib in healthy male volunteers

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12 December 2020

Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection

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12 December 2020

Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain

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12 December 2020

The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro

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12 December 2020

The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.

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12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

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12 December 2020

Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls

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12 December 2020

Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications

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12 December 2020

Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

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12 December 2020

NSAIDs and the kidney revisited: are selective cyclooxygenase-2 inhibitors safe?

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12 December 2020

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism

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12 December 2020

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese

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12 December 2020

Clinical pharmacokinetic considerations in the elderly. An update

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12 December 2020

Interindividual variability in sensitivity to warfarin--Nature or nurture?

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12 December 2020

Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.

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12 December 2020

Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

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12 December 2020

Measures of exposure versus measures of rate and extent of absorption

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12 December 2020

Is diclofenac a valuable CYP2C9 probe in humans?

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12 December 2020

Including elderly people in clinical trials

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12 December 2020

COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?

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12 December 2020

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

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12 December 2020

Prescribing for the elderly patient: why do we need to exercise caution?

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12 December 2020

Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human

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12 December 2020

Drug dosage in the elderly. Is it rational?

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12 December 2020

The pharmacokinetics of non-steroidal anti-inflammatory drugs in the elderly

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12 December 2020

Clinical economics review: gastrointestinal complications of non-steroidal anti-inflammatory drugs

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12 December 2020

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12 December 2020

Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor

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12 December 2020

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

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12 December 2020

Pharmacokinetic characteristics for extent of absorption and clearance in drug/drug interaction studies

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12 December 2020

Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited

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12 December 2020

Aging: a global issue

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12 December 2020

Drug metabolism and drug interactions in the elderly

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12 December 2020

High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population

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12 December 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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12 December 2020

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

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12 December 2020

Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences

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12 December 2020

Pharmacokinetic-pharmacodynamic and metabolite modeling with TopFit.

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12 December 2020

Frequency of cytochrome P450 2C9 mutant alleles in a Korean population

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12 December 2020

The coxibs, selective inhibitors of cyclooxygenase-2.

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12 December 2020

Genetic analysis of the human cytochrome P450 CYP2C9 locus.

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12 December 2020

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics

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12 December 2020

Pharmacokinetic Optimisation of Drug Therapy in Elderly Patients

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12 December 2020

Gerontokinetics--a reappraisal

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12 December 2020

Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?

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12 December 2020

10.2165/00003088-200342030-00003

Identifiers

DOI

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Dimensions Publication ID

2 August 2017

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