(Q36294092)

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Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity

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scholarly article

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12 February 2020

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity (English)

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12 February 2020

Kenneth A. Jacobson

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12 February 2020

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Zhan-Guo Gao

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12 February 2020

Silvia Paoletta

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Silvia Paoletta

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12 February 2020

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Dilip K Tosh

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12 February 2020

Francesca Deflorian

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Francesca Deflorian

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12 February 2020

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Khai Phan

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12 February 2020

Steven M Moss

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12 February 2020

Xiaohui Jiang

7

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12 February 2020

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10 September 2012

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12 February 2020

Journal of Medicinal Chemistry

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12 February 2020

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12 February 2020

18

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12 February 2020

8075-8090

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12 February 2020

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats

1 reference

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30 September 2017

Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders

1 reference

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30 September 2017

Reorganizing the protein space at the Universal Protein Resource (UniProt)

1 reference

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30 September 2017

Partial adenosine A1 receptor agonists for cardiovascular therapies

1 reference

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30 September 2017

Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging

1 reference

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30 September 2017

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Structure of an agonist-bound human A2A adenosine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.

1 reference

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30 September 2017

Recent developments in adenosine receptor ligands and their potential as novel drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Adenosine amine congener mitigates noise-induced cochlear injury

1 reference

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30 September 2017

Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Discovery of antiepileptic drugs

1 reference

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30 September 2017

N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors

1 reference

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30 September 2017

Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

1 reference

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30 September 2017

N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors

1 reference

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30 September 2017

The influence of DMPK as an integrated partner in modern drug discovery

1 reference

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30 September 2017

Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

1 reference

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30 September 2017

Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides

1 reference

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30 September 2017

Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463139

30 September 2017

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects

1 reference

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30 September 2017

Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils

1 reference

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30 September 2017

Adenosine receptor prodrugs: synthesis and biological activity of derivatives of potent, A1-selective agonists

1 reference

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30 September 2017

The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models.

1 reference

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30 September 2017

Modification of seizure activity by electrical stimulation. II. Motor seizure

1 reference

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30 September 2017

Screening and characterization of antiepileptic drugs with rapidly recurring hippocampal seizures in rats

1 reference

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30 September 2017

Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation

1 reference

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30 September 2017

Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism.

1 reference

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30 September 2017

Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.

1 reference

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29 June 2018

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models

1 reference

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29 June 2018

Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death

1 reference

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29 June 2018

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

1 reference

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29 June 2018

Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.

1 reference

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29 June 2018

Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow.

1 reference

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29 June 2018

Adenosine A1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus

1 reference

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29 June 2018

Adenosine A1 receptors are crucial in keeping an epileptic focus localized.

1 reference

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22 September 2018

Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice.

1 reference

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22 September 2018

Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats

1 reference

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22 September 2018

Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy

1 reference

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22 September 2018

Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice

1 reference

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22 September 2018

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

1 reference

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22 September 2018

Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

1 reference

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22 September 2018

The search for new drugs against epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1 adenosine receptor agonists and their potential therapeutic applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the Role of the Crystal Environment in Determining Protein Side-chain Conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statisical logic in the monitoring of reactions to therapeutic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A note on a simple apparatus for detecting neurological deficit in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22921089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM300965A

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22921089%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22921089%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22921089%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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