(Q36294938)

English

Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Aherne GW

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ward E

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Lawrence N

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Dobinson D

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Clarke SJ

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Musgrove H

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Sutcliffe F

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Stephens T

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jackman AL

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

1 January 1998

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

77

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

221-226

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Folate-based thymidylate synthase inhibitors as anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Enhancement of thymidylate synthase inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Development of an assay for the estimation of N10-propargyl-5,8-dideazafolic acid polyglutamates in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

30 September 2017

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

Radioimmunoassay for methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

Development and application of a radioimmunoassay for methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151243

29 June 2018

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

‘Tomudex’ (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of erythrocyte methotrexate after high-dose methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation and identification of methotrexate and its metabolites, 7-hydroxymethotrexate and polyglutamates, in human tissues by reversed-phase high-performance liquid chromatography coupled with radioimmunoassay

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9460992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.1998.37

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

release_ciphj6ppfje5nogpfwjthocvia

1 reference

https://api.fatcat.wiki/v0/release/ciphj6ppfje5nogpfwjthocvia

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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