(Q36297331)

13 August 2017

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title

Insulin resistance: a metabolic pathway to chronic liver disease (English)

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13 August 2017

chronic liver disease

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1

Elisabetta Bugianesi

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13 August 2017

Arthur J McCullough

2

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PubMed ID

16250043

13 August 2017

Giulio Marchesini

series ordinal

3

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PubMed ID

16250043

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

42

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13 August 2017

5

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13 August 2017

987-1000

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Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction

13 August 2017

1 reference

7 January 2021

Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus.

1 reference

7 January 2021

Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose

1 reference

7 January 2021

Insulin release and peripheral sensitivity at the oral glucose tolerance test.

1 reference

7 January 2021

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

1 reference

7 January 2021

Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.

1 reference

7 January 2021

A model-based method for assessing insulin sensitivity from the oral glucose tolerance test

1 reference

7 January 2021

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

7 January 2021

Clinical review 26: Insulin resistance in obese and nonobese man.

1 reference

7 January 2021

How good a marker is insulin level for insulin resistance?

1 reference

7 January 2021

Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.

1 reference

7 January 2021

The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values.

1 reference

7 January 2021

Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.

1 reference

7 January 2021

Validation of simple indices to assess insulin sensitivity based on the oral glucose tolerance test in the Japanese population

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7 January 2021

Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test

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7 January 2021

Association of nonalcoholic fatty liver disease with insulin resistance.

1 reference

7 January 2021

Insulin resistance in non-alcoholic steatohepatitis

1 reference

7 January 2021

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

1 reference

7 January 2021

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

1 reference

7 January 2021

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

1 reference

7 January 2021

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1 reference

7 January 2021

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

1 reference

7 January 2021

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

1 reference

7 January 2021

Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes

1 reference

7 January 2021

Dose-response effect of elevated plasma free fatty acid on insulin signaling

1 reference

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

7 January 2021

Metabolic and molecular basis of insulin resistance

1 reference

7 January 2021

Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance

1 reference

7 January 2021

Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle

1 reference

7 January 2021

Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes

1 reference

7 January 2021

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

7 January 2021

Mitochondrial abnormalities in non-alcoholic steatohepatitis

1 reference

7 January 2021

Determinants of postabsorptive endogenous glucose output in non-diabetic subjects. European Group for the Study of Insulin Resistance (EGIR).

1 reference

7 January 2021

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

7 January 2021

Cellular mechanisms of insulin resistance

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7 January 2021

Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance

1 reference

7 January 2021

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

1 reference

7 January 2021

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

7 January 2021

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

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7 January 2021

Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism

1 reference

7 January 2021

Systemic and regional free fatty acid metabolism in type 2 diabetes

1 reference

7 January 2021

Metabolic effects of visceral fat accumulation in type 2 diabetes

1 reference

7 January 2021

Skeletal muscle triglyceride levels are inversely related to insulin action.

1 reference

7 January 2021

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

1 reference

7 January 2021

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

7 January 2021

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

1 reference

7 January 2021

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

1 reference

7 January 2021

Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy

1 reference

7 January 2021

Failure of adipocyte differentiation causes type II diabetes mellitus?

1 reference

7 January 2021

Insulin resistance and chronic cardiovascular inflammatory syndrome

1 reference

7 January 2021

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

1 reference

7 January 2021

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

1 reference

7 January 2021

Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk

1 reference

7 January 2021

Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients

1 reference

7 January 2021

Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals

1 reference

7 January 2021

Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity

1 reference

7 January 2021

Adiponectin, hepatocellular dysfunction and insulin sensitivity

1 reference

7 January 2021

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

1 reference

7 January 2021

Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin

1 reference

7 January 2021

The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology

1 reference

7 January 2021

Adiponectin and its receptors in non-alcoholic steatohepatitis.

1 reference

7 January 2021

Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics

1 reference

7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

7 January 2021

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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7 January 2021

Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients

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7 January 2021

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

1 reference

7 January 2021

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

1 reference

7 January 2021

Cytokines in alcoholic and nonalcoholic steatohepatitis

1 reference

7 January 2021

Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues

1 reference

7 January 2021

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

7 January 2021

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

1 reference

7 January 2021

1 reference

7 January 2021

Leptin and liver fibrosis: A matter of fat

1 reference

7 January 2021

Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis

1 reference

7 January 2021

Leptin is essential for the hepatic fibrogenic response to chronic liver injury

1 reference

7 January 2021

Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women.

1 reference

7 January 2021

Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

7 January 2021

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

1 reference

7 January 2021

Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes

1 reference

7 January 2021

The hormone resistin links obesity to diabetes

1 reference

7 January 2021

Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production

1 reference

7 January 2021

Role of resistin in diet-induced hepatic insulin resistance

1 reference

7 January 2021

Angiotensinogen, adipocyte differentiation and fat mass enlargement.

1 reference

7 January 2021

Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats

1 reference

7 January 2021

Steatohepatitis: a tale of two "hits"?

1 reference

7 January 2021

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

7 January 2021

Is obesity an inflammatory condition?

1 reference

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

7 January 2021

Increased levels of acute-phase serum proteins in diabetes.

1 reference

7 January 2021

Relation between iron stores and non-insulin dependent diabetes in men: case-control study

1 reference

7 January 2021

Antiinflammatory and antiarteriosclerotic effects of pioglitazone

1 reference

7 January 2021

Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.

1 reference

7 January 2021

Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women

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7 January 2021

Cardiovascular morbidity and mortality associated with the metabolic syndrome

1 reference

7 January 2021

Comment on the provisional report from the WHO consultation

1 reference

7 January 2021

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

1 reference

7 January 2021

Clinical features and natural history of nonalcoholic steatosis syndromes

1 reference

7 January 2021

Prevalence of and risk factors for hepatic steatosis in Northern Italy

1 reference

7 January 2021

Obesity and liver disease

1 reference

7 January 2021

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors

1 reference

7 January 2021

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1 reference

7 January 2021

Diabetes mellitus and the liver

1 reference

7 January 2021

High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes

1 reference

7 January 2021

Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis

1 reference

7 January 2021

Insulin resistance in essential hypertension

1 reference

7 January 2021

Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance

1 reference

7 January 2021

WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes

1 reference

7 January 2021

Metformin in non-alcoholic steatohepatitis.

1 reference

7 January 2021

Metformin in the treatment of patients with non-alcoholic steatohepatitis

1 reference

7 January 2021

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial

1 reference

7 January 2021

A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease

1 reference

7 January 2021

Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis

1 reference

7 January 2021

A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis

1 reference

7 January 2021

Effect of pioglitazone on biochemical indices of non-alcoholic fatty liver disease in upper body obesity

1 reference

7 January 2021

Intermittent disconjugate gaze: a novel finding in nonalcoholic steatohepatitis and cryptogenic cirrhosis

1 reference

7 January 2021

Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion

1 reference

7 January 2021

The metabolic syndrome and chronic kidney disease in U.S. adults

1 reference

7 January 2021

Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults

1 reference

7 January 2021

A novel view of metabolic syndrome

1 reference

7 January 2021

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

1 reference

7 January 2021

Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds

1 reference

7 January 2021

Genetics of the metabolic syndrome

1 reference

7 January 2021

Challenges and strategies for investigating the genetic complexity of common human diseases

1 reference

7 January 2021

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

1 reference

7 January 2021

A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.20920

1 reference

13 August 2017

1 reference

PubMed ID

16250043