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Precise regulation of porcupine activity is required for physiological Wnt signaling.
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Europe PubMed Central
PMC publication ID
3464525
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
title
Precise regulation of porcupine activity is required for physiological Wnt signaling
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
author
David M. Virshup
series ordinal
2
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Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
author name string
Kyle D Proffitt
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1
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Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
language of work or name
English
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publication date
10 August 2012
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Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
published in
Journal of Biological Chemistry
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Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
volume
287
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
issue
41
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
page(s)
34167-34178
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stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
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Structural basis of Wnt recognition by Frizzled
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30 September 2017
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation
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30 September 2017
Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome)
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30 September 2017
Porcupine-mediated lipidation is required for Wnt recognition by Wls.
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30 September 2017
p24 proteins are required for secretion of Wnt ligands
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30 September 2017
Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences
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A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
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β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target
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Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
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PubMed Central
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30 September 2017
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
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PubMed Central
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High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
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Mutation update for the PORCN gene.
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30 September 2017
Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins
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30 September 2017
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
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30 September 2017
Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.
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PubMed Central
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WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
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30 September 2017
Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models
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30 September 2017
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
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30 September 2017
Goltz-Gorlin (focal dermal hypoplasia) and the microphthalmia with linear skin defects (MLS) syndrome: no evidence of genetic overlap
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30 September 2017
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
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30 September 2017
Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone
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30 September 2017
Regulation of Wnt protein secretion and its role in gradient formation
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30 September 2017
The Trichoplax genome and the nature of placozoans
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30 September 2017
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity
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30 September 2017
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
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30 September 2017
Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
The many ways of Wnt in cancer
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
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30 September 2017
Wnt proteins are lipid-modified and can act as stem cell growth factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
30 September 2017
Direct and long-range action of a wingless morphogen gradient
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
29 June 2018
Loss of Porcupine impairs convergent extension during gastrulation in zebrafish
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
PORCN mutations and variants identified in patients with focal dermal hypoplasia through diagnostic gene sequencing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Novel PORCN mutations in focal dermal hypoplasia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
PORCN mutations in focal dermal hypoplasia: coping with lethality
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464525
retrieved
22 September 2018
Identifiers
DOI
10.1074/JBC.M112.381970
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
PMC publication ID
3464525
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
PubMed publication ID
22888000
1 reference
stated in
Europe PubMed Central
PMC publication ID
3464525
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
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