(Q36301713)

13 August 2017

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction (English)

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13 August 2017

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Gaetano Zizzo

1

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author name string

Brendan A Hilliard

series ordinal

2

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13 August 2017

Marc Monestier

series ordinal

3

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13 August 2017

Philip L Cohen

series ordinal

4

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13 August 2017

language of work or name

English

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publication date

31 August 2012

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13 August 2017

Journal of Immunology

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13 August 2017

189

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13 August 2017

7

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13 August 2017

3508-3520

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3465703/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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30 September 2017

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Disturbances of apoptotic cell clearance in systemic lupus erythematosus

30 September 2017

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Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency

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Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses

30 September 2017

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TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

30 September 2017

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TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages

30 September 2017

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CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages

30 September 2017

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PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

30 September 2017

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30 September 2017

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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

30 September 2017

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MerTK regulates thymic selection of autoreactive T cells

30 September 2017

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Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages

30 September 2017

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TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer

30 September 2017

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The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages

30 September 2017

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CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages.

30 September 2017

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Macrophage activation and polarization

30 September 2017

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Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells

30 September 2017

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Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression

30 September 2017

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Clearance of apoptotic and necrotic cells and its immunological consequences

30 September 2017

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Effects of high-dose methylprednisolone therapy on coagulation factors in patients with acute immune thrombocytopenic purpura

30 September 2017

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A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.

30 September 2017

1 reference

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The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Mer receptor tyrosine kinase signaling participates in platelet function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

30 September 2017

1 reference

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Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy

30 September 2017

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Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice.

30 September 2017

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Alternative activation of macrophages

30 September 2017

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Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase

30 September 2017

1 reference

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Total cytokine immunoassay: a more accurate method of cytokine measurement?

30 September 2017

1 reference

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Phagocytosis and clearance of apoptotic cells is mediated by MER.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Human monocytes express CD163, which is upregulated by IL-10 and identical to p155.

30 September 2017

1 reference

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The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.

30 September 2017

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

TAM receptors and the clearance of apoptotic cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activat

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Macrophage colony-stimulating factor (CSF-1) gene expression in human T-lymphocyte clones.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Platelet-induced expression of FcγRIII (CD16) on human monocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Peripheral blood CD14high CD16+ monocytes are main producers of IL-10.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

IL-10-producing macrophages preferentially clear early apoptotic cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Interleukin-10 concentration determined by sandwich enzyme-linked immunosorbent assay is unrepresentative of bioactivity in murine blood

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

IL-10 expression profiling in human monocytes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465703

Immunosuppressive effects of apoptotic cells

22 September 2018

1 reference

12 December 2020

Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production

1 reference

12 December 2020

Interaction of human peripheral blood monocytes with apoptotic polymorphonuclear cells

1 reference

12 December 2020

Enhancement of macrophage colony-stimulating factor-induced growth and differentiation of human monocytes by interleukin-10

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1200662

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

22942426

1 reference