(Q36302418)

13 August 2017

Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences (English)

1 reference

13 August 2017

Patricia Heyn

1

0 references

Pavel Tomancak

series ordinal

3

object named as

Pavel Tomancak

1 reference

13 August 2017

Alex T Kalinka

2

1 reference

PMCID

4654234

13 August 2017

Karla M Neugebauer

series ordinal

4

1 reference

PMCID

4654234

13 August 2017

language of work or name

English

0 references

publication date

14 November 2014

1 reference

13 August 2017

1 reference

13 August 2017

37

1 reference

13 August 2017

2

1 reference

13 August 2017

148-154

1 reference

Transcript length mediates developmental timing of gene expression across Drosophila

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Coupling mRNA processing with transcription in time and space.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Counting on co-transcriptional splicing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Alternative cleavage and polyadenylation: the long and short of it

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Global patterns of tissue-specific alternative polyadenylation in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Neural-specific elongation of 3' UTRs during Drosophila development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Pause locally, splice globally

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Intronic delay is essential for oscillatory expression in the segmentation clock

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The maternal-to-zygotic transition: a play in two acts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The spliceosome: design principles of a dynamic RNP machine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Primary microRNA transcripts are processed co-transcriptionally.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Intron length increases oscillatory periods of gene expression in animal cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Rapidly regulated genes are intron poor.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Intron delays and transcriptional timing during development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Promoter-proximal introns in Arabidopsis thaliana are enriched in dispersed signals that elevate gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription site

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Cell cycle in mouse development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The SR protein SRp38 represses splicing in M phase cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Promoter proximal splice sites enhance transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Selective constraint in intergenic regions of human and mouse genomes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Inefficient processing impairs release of RNA from the site of transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Transcription-dependent induction of G1 phase during the zebra fish midblastula transition.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

30 September 2017

https://api.crossref.org/works/10.1002%2FBIES.201400138

Introns increase transcriptional efficiency in transgenic mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Control of endogenous gene expression timing by introns

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Distinct patterns of expression and evolution of intronless and intron-containing mammalian genes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Mitotic repression of the transcriptional machinery.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Characterization of the unusually rapid cell cycles during rat gastrulation.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Loss of gene function through rapid mitotic cycles in the Drosophila embryo

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

Removal of retained introns regulates translation in the rapidly developing gametophyte of Marsilea vestita

29 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

First exon length controls active chromatin signatures and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Spatial and temporal patterns of E74 transcription during Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

The earliest transcribed zygotic genes are short, newly evolved, and different across species

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

G2 acquisition by transcription-independent mechanism at the zebrafish midblastula transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Parameters controlling transcriptional activation during early Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Chromatin organization marks exon-intron structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

Global Analysis of Nascent RNA Reveals Transcriptional Pausing in Terminal Exons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400138

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654234

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25400101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effect of gene concentration and relative gene dosage on gene output in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25400101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25400101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/BIES.201400138

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

4654234