(Q36305439)

13 August 2017

1 reference

title

Cancer treatment and pharmacogenetics of cytochrome P450 enzymes (English)

1 reference

13 August 2017

Ron H N van Schaik

1

1 reference

13 August 2017

publication date

1 December 2005

1 reference

Investigational New Drugs

13 August 2017

published in

1 reference

13 August 2017

volume

23

1 reference

13 August 2017

issue

6

1 reference

13 August 2017

page(s)

513-522

1 reference

Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications

13 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-005-4019-1

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-005-4019-1

Effects of St. John's wort on irinotecan metabolism

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-005-4019-1

The genetic determinants of the CYP3A5 polymorphism

21 January 2018

1 reference

12 December 2020

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro

1 reference

12 December 2020

Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver

1 reference

12 December 2020

The CYP3A4*3 allele: is it really rare?

1 reference

12 December 2020

Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population

1 reference

12 December 2020

Bioactivation of cyclophosphamide: the role of polymorphic CYP2C enzymes

1 reference

12 December 2020

A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels

1 reference

12 December 2020

Genetic contribution to variable human CYP3A-mediated metabolism

1 reference

12 December 2020

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

1 reference

12 December 2020

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

12 December 2020

Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans

1 reference

12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

1 reference

12 December 2020

Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians

1 reference

12 December 2020

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

1 reference

12 December 2020

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

1 reference

12 December 2020

Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients

1 reference

12 December 2020

Thalidomide metabolism by the CYP2C subfamily.

1 reference

12 December 2020

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

1 reference

12 December 2020

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

1 reference

12 December 2020

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

12 December 2020

Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase

1 reference

12 December 2020

CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism

1 reference

12 December 2020

Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

1 reference

12 December 2020

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

1 reference

12 December 2020

Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online

1 reference

12 December 2020

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism

1 reference

12 December 2020

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

1 reference

12 December 2020

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

1 reference

12 December 2020

Does the CYP3A5*3 polymorphism affect in vivo drug elimination?

1 reference

12 December 2020

Bimodal distribution of renal cytochrome P450 3A activity in humans

1 reference

12 December 2020

Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions

1 reference

12 December 2020

Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation

1 reference

12 December 2020

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

1 reference

12 December 2020

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

1 reference

12 December 2020

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

1 reference

12 December 2020

Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship

1 reference

12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

12 December 2020

Modulation of irinotecan metabolism by ketoconazole

1 reference

12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

12 December 2020

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

1 reference

12 December 2020

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

1 reference

12 December 2020

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

1 reference

12 December 2020

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

1 reference

12 December 2020

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population

1 reference

12 December 2020

The contribution of cytochrome P450 to the metabolism of tegafur in human liver

1 reference

12 December 2020

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver

1 reference

12 December 2020

Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift.

1 reference

12 December 2020

A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes.

1 reference

12 December 2020

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes

1 reference

12 December 2020

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 reference

12 December 2020

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

1 reference

12 December 2020

Cytochrome P450 CYP3A5 in the human anterior pituitary gland

1 reference

12 December 2020

CYP3A5 variant allele frequencies in Dutch Caucasians

1 reference

12 December 2020

In vitro and in vivo drug interactions involving human CYP3A

1 reference

12 December 2020

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

1 reference

12 December 2020

Gender difference in ifosfamide metabolism by human liver microsomes

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

1 reference

12 December 2020

Irinotecan pathway genotype analysis to predict pharmacokinetics

1 reference

12 December 2020

The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance

1 reference

12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

1 reference

12 December 2020

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone

1 reference

12 December 2020

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

1 reference

12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

1 reference

12 December 2020

Identification of a novel splice-site mutation in the CYP1A2 gene

1 reference

12 December 2020

Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.

1 reference

12 December 2020

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

1 reference

12 December 2020

RESPONSE: re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

12 December 2020

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations

1 reference

12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

12 December 2020

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

1 reference

12 December 2020

Novel mutations of CYP3A4 in Chinese

1 reference

12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

12 December 2020

Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions

1 reference

12 December 2020

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

1 reference

12 December 2020

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

1 reference

12 December 2020

CYP2C9 allelic variants: ethnic distribution and functional significance

1 reference

12 December 2020

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

1 reference

12 December 2020

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

1 reference

12 December 2020

Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism

1 reference

12 December 2020

High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity

1 reference

12 December 2020

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

1 reference

12 December 2020

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

[Dystonic movements: a possible secondary effect of gabapentin]

1 reference

12 December 2020

Cytochrome P450 3A: ontogeny and drug disposition

1 reference

12 December 2020

Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia

1 reference

12 December 2020

Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2

1 reference

12 December 2020

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

1 reference

12 December 2020

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

12 December 2020

Expression of CYP1A1 and CYP1A2 genes in human liver

1 reference

12 December 2020

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

1 reference

12 December 2020

Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes

1 reference

12 December 2020

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

12 December 2020

The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer

1 reference

12 December 2020

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

1 reference

12 December 2020

Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans

1 reference

12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

1 reference

12 December 2020

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

1 reference

12 December 2020

A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur

1 reference

12 December 2020

Cytochrome P450-dependent metabolism of gefitinib

1 reference

12 December 2020

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

12 December 2020

CYP3A4 and MDR1 alleles in a Portuguese population

1 reference

12 December 2020

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

1 reference

12 December 2020

10.1007/S10637-005-4019-1

Identifiers

DOI

1 reference

13 August 2017

1 reference