(Q36312081)

13 August 2017

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title

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention (English)

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13 August 2017

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N P Vermeulen

1

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13 August 2017

J G Bessems

series ordinal

2

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13 August 2017

R Van de Straat

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 January 1992

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13 August 2017

published in

Drug Metabolism Reviews

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13 August 2017

volume

24

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13 August 2017

issue

3

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13 August 2017

page(s)

367-407

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Paracetamol Overdosage Pharmacological Considerations and Clinical Management

13 August 2017

cites work

1 reference

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Genotoxic effects of paracetamol in V79 Chinese hamster cells

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Additive effects of inducers and fasting on acetaminophen hepatotoxicity.

21 January 2018

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Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

21 January 2018

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Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats

21 January 2018

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

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Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol

21 January 2018

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Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

21 January 2018

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Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate

21 January 2018

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Liver and kidney damage induced by N-hydroxyparacetamol

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Oxygen activation by cytochrome P-450.

21 January 2018

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Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets

21 January 2018

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21 January 2018

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Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine

21 January 2018

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21 January 2018

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21 January 2018

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Carbon tetrachloride hepatotoxicity: an example of lethal cleavage

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice

21 January 2018

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Acetaminophen hepatotoxicity: studies on the mechanism of cysteamine protection

21 January 2018

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The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

21 January 2018

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Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.

21 January 2018

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Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile

21 January 2018

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21 January 2018

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Comparative toxicities and analgesic activities of three monomethylated analogues of acetaminophen

21 January 2018

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Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice

21 January 2018

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Structure-activity study of paracetamol analogs: inhibition of replicative DNA synthesis in V79 Chinese hamster cells

21 January 2018

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N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes.

21 January 2018

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On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes

21 January 2018

1 reference

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Metabolism of acetaminophen by cultured rat hepatocytes. Depletion of protein thiol groups without any loss of viability

21 January 2018

1 reference

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Prevention of paracetamol-induced liver injury by fructose

21 January 2018

1 reference

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10.3109/03602539208996298

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference