(Q36325591)

13 August 2017

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title

Semaphorins command cells to move (English)

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13 August 2017

Robert P Kruger

1

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PubMed ID

16314868

13 August 2017

Jennifer Aurandt

series ordinal

2

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PubMed ID

16314868

13 August 2017

Kun-Liang Guan

series ordinal

3

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13 August 2017

1 October 2005

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Nature Reviews Molecular Cell Biology

13 August 2017

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13 August 2017

6

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13 August 2017

789-800

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13 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrm1740

13 August 2017

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cites work

A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR

1 reference

Plexin A is a neuronal semaphorin receptor that controls axon guidance

31 March 2020

1 reference

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

31 March 2020

1 reference

The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

31 March 2020

1 reference

Semaphorin junction: making tracks toward neural connectivity

31 March 2020

1 reference

Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee

31 March 2020

1 reference

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

31 March 2020

1 reference

Structure of the semaphorin-3A receptor binding module

31 March 2020

1 reference

Plexin: a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions

31 March 2020

1 reference

1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold

31 March 2020

1 reference

Plexina1 autoinhibition by the plexin sema domain.

31 March 2020

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Functional regulation of semaphorin receptors by proprotein convertases

31 March 2020

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Neuropilin is a semaphorin III receptor

31 March 2020

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Neuropilin is a receptor for the axonal chemorepellent Semaphorin III

31 March 2020

1 reference

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

31 March 2020

1 reference

The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.

31 March 2020

1 reference

Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

31 March 2020

1 reference

Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules

31 March 2020

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Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

31 March 2020

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Neuronal cdc2-like kinase

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

31 March 2020

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The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance

31 March 2020

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Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

31 March 2020

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Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones

31 March 2020

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Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

31 March 2020

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Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling

31 March 2020

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

31 March 2020

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The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

31 March 2020

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Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

31 March 2020

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The activity of the plexin-A1 receptor is regulated by Rac

31 March 2020

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The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

31 March 2020

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

31 March 2020

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Rac1 mediates collapsin-1-induced growth cone collapse

31 March 2020

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Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1

31 March 2020

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Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.

31 March 2020

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The semaphorin 3A receptor may directly regulate the activity of small GTPases.

31 March 2020

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Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

31 March 2020

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Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

31 March 2020

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

31 March 2020

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Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility

31 March 2020

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Signalling mechanisms mediating neuronal responses to guidance cues

31 March 2020

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Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons

31 March 2020

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Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

31 March 2020

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Ras GTPases: integrins' friends or foes?

31 March 2020

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R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells

31 March 2020

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Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

31 March 2020

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The function of semaphorins during nervous system development

31 March 2020

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Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance

31 March 2020

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An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells.

31 March 2020

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Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum.

31 March 2020

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Transmembrane sema4E guides branchiomotor axons to their targets in zebrafish.

31 March 2020

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Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events.

31 March 2020

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Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient mice.

31 March 2020

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Netrin-1 and semaphorin 3A promote or inhibit cortical axon branching, respectively, by reorganization of the cytoskeleton.

31 March 2020

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Stereotyped Pruning of Long Hippocampal Axon Branches Triggered by Retraction Inducers of the Semaphorin Family

31 March 2020

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MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion

31 March 2020

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Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation

31 March 2020

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Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse.

31 March 2020

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Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM.

31 March 2020

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Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse

31 March 2020

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The integrin family of cell adhesion molecules has multiple functions within the CNS.

31 March 2020

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Nerve growth factor stimulates the accumulation of beta1 integrin at the tips of filopodia in the growth cones of sympathetic neurons

31 March 2020

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Regulation of neurite outgrowth by integrin activation.

31 March 2020

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A novel cAMP-dependent pathway activates neuronal integrin function in retinal neurons.

31 March 2020

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Blood vessels and nerves: common signals, pathways and diseases

31 March 2020

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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

31 March 2020

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Semaphorin-plexin signaling guides patterning of the developing vasculature.

31 March 2020

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Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1.

31 March 2020

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Molecular cloning, expression, and activity of zebrafish semaphorin Z1a.

31 March 2020

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Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development

31 March 2020

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Semaphorin III is needed for normal patterning and growth of nerves, bones and heart

31 March 2020

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Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling

31 March 2020

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Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

31 March 2020

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Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway

31 March 2020

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Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration

31 March 2020

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Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils

31 March 2020

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Semaphorins in interactions between T cells and antigen-presenting cells

31 March 2020

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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

31 March 2020

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Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

31 March 2020

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Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells

31 March 2020

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Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses

31 March 2020

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Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration

31 March 2020

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Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively

31 March 2020

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CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

31 March 2020

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Integrins and T cell-mediated immunity

31 March 2020

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The regulation of actin remodeling during T-cell-APC conjugate formation

31 March 2020

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The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

31 March 2020

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Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns

31 March 2020

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Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

31 March 2020

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Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

31 March 2020

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Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect

31 March 2020

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Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration

31 March 2020

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Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

31 March 2020

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R-Ras promotes tumor growth of cervical epithelial cells

31 March 2020

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Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells

31 March 2020

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Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display

31 March 2020

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Integrin signalling during tumour progression

31 March 2020

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The versatile roles of "axon guidance" cues in tissue morphogenesis.

31 March 2020

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An Eph receptor regulates integrin activity through R-Ras

31 March 2020

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Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis

31 March 2020

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Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells

31 March 2020

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Regulation of dendritic length and branching by semaphorin 3A.

31 March 2020

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Semaphorin 3A is a chemoattractant for cortical apical dendrites.

31 March 2020

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Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.

31 March 2020

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Nervy links protein kinase a to plexin-mediated semaphorin repulsion.

31 March 2020

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Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo.

31 March 2020

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MICAL, a novel CasL interacting molecule, associates with vimentin

31 March 2020

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Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95

31 March 2020

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Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95

31 March 2020

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The human semaphorin-like leukocyte cell surface molecule CD100 associates with a serine kinase activity.

31 March 2020

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The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

31 March 2020

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A novel transmembrane semaphorin can bind c-src.

31 March 2020

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Molecular cloning of a novel member of semaphorin family genes, semaphorin Z.

31 March 2020

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Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila.

31 March 2020

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Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins.

31 March 2020

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Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones

31 March 2020

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Plexin-B3 is a functional receptor for semaphorin 5A.

31 March 2020

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Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion".

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1740

1 reference

13 August 2017

1 reference

PubMed ID

16314868