(Q35906078)

11 August 2017

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title

Integrin signalling during tumour progression (English)

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11 August 2017

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Wenjun Guo

1

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PubMed ID

15459662

11 August 2017

Filippo G Giancotti

series ordinal

2

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11 August 2017

1 October 2004

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Nature Reviews Molecular Cell Biology

11 August 2017

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11 August 2017

5

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11 August 2017

816-826

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11 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrm1490

11 August 2017

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1 reference

Integrins: bidirectional, allosteric signaling machines

31 March 2020

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Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

31 March 2020

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Sensing the environment: a historical perspective on integrin signal transduction

31 March 2020

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Networks and crosstalk: integrin signalling spreads.

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Putting tumours in context

31 March 2020

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Stromal effects on mammary gland development and breast cancer

31 March 2020

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Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?

31 March 2020

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Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

31 March 2020

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Molecular mechanisms of lymphangiogenesis in health and disease

31 March 2020

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Integrin activation controls metastasis in human breast cancer

31 March 2020

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Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

31 March 2020

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

31 March 2020

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31 March 2020

Inflammation and cancer

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Adhesion events in angiogenesis.

31 March 2020

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A reevaluation of integrins as regulators of angiogenesis

31 March 2020

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Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin

31 March 2020

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Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells

31 March 2020

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Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells

31 March 2020

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Changes in integrin receptors on oncogenically transformed cells.

31 March 2020

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

31 March 2020

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A causal role for E-cadherin in the transition from adenoma to carcinoma

31 March 2020

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Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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The snail superfamily of zinc-finger transcription factors

31 March 2020

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Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

31 March 2020

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Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function

31 March 2020

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

31 March 2020

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Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

31 March 2020

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Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

31 March 2020

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

31 March 2020

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Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

31 March 2020

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Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact

31 March 2020

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

31 March 2020

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TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

31 March 2020

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

31 March 2020

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Epithelial induction of stromal tenascin in the mouse mammary gland: from embryogenesis to carcinogenesis.

31 March 2020

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The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain

31 March 2020

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Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again

31 March 2020

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

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FAK regulates biological processes important for the pathogenesis of cancer

31 March 2020

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FAK integrates growth-factor and integrin signals to promote cell migration

31 March 2020

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

31 March 2020

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

31 March 2020

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Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

31 March 2020

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

31 March 2020

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Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

31 March 2020

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Regulation of cell motility by mitogen-activated protein kinase

31 March 2020

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JNK phosphorylates paxillin and regulates cell migration

31 March 2020

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Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

31 March 2020

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c-Jun is essential for organization of the epidermal leading edge

31 March 2020

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Cell migration: Rho GTPases lead the way

31 March 2020

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

31 March 2020

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Cellular motility driven by assembly and disassembly of actin filaments

31 March 2020

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

31 March 2020

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Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

31 March 2020

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Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

31 March 2020

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

31 March 2020

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

31 March 2020

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

31 March 2020

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Genomic analysis of metastasis reveals an essential role for RhoC

31 March 2020

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How matrix metalloproteinases regulate cell behavior

31 March 2020

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Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma

31 March 2020

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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

31 March 2020

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Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

31 March 2020

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uPAR: a versatile signalling orchestrator

31 March 2020

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FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

31 March 2020

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Differential regulation of cell motility and invasion by FAK

31 March 2020

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

31 March 2020

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Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin

31 March 2020

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Laminin isoforms in tumor invasion, angiogenesis and metastasis

31 March 2020

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Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5.

31 March 2020

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Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

31 March 2020

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Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

31 March 2020

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The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

31 March 2020

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

31 March 2020

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Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion

31 March 2020

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

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beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

31 March 2020

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Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors

31 March 2020

1 reference

EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

31 March 2020

1 reference

Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines.

31 March 2020

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The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

31 March 2020

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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

31 March 2020

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Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

31 March 2020

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Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3.

31 March 2020

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In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells

31 March 2020

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Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis

31 March 2020

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Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2.

31 March 2020

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Interaction of endostatin with integrins implicated in angiogenesis

31 March 2020

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Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin

31 March 2020

1 reference

31 March 2020

Integrins and anoikis

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Control of adhesion-dependent cell survival by focal adhesion kinase

31 March 2020

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

1 reference

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression

31 March 2020

1 reference

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

31 March 2020

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The IGF axis and programmed cell death

31 March 2020

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PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

31 March 2020

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Control of apoptosis by p53.

31 March 2020

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

31 March 2020

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Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis

31 March 2020

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Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

31 March 2020

1 reference

Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

31 March 2020

1 reference

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

31 March 2020

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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

31 March 2020

1 reference

A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor

31 March 2020

1 reference

Activation of p53 function in carcinoma cells by the alpha6beta4 integrin

31 March 2020

1 reference

Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis

31 March 2020

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Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth

31 March 2020

1 reference

Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells

31 March 2020

1 reference

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

31 March 2020

1 reference

Integrin signalling and tyrosine phosphorylation: just the FAKs?

31 March 2020

1 reference

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

31 March 2020

1 reference

Src kinase activation by direct interaction with the integrin β cytoplasmic domain

31 March 2020

1 reference

Compartmentalization of integrin α6β4 signaling in lipid rafts

31 March 2020

1 reference

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

31 March 2020

1 reference

Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion

31 March 2020

1 reference

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion

31 March 2020

1 reference

Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

31 March 2020

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PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1490

1 reference

11 August 2017

1 reference

PubMed ID

15459662