(Q35564604)

8 August 2017

1 reference

title

Ras GTPases: integrins' friends or foes? (English)

1 reference

8 August 2017

1 reference

23 March 2024

author

Lawrence E Goldfinger

2

object named as

Lawrence E Goldfinger

1 reference

8 August 2017

Kayoko Kinbara

1

1 reference

8 August 2017

Malene Hansen

3

1 reference

8 August 2017

Fan-Li Chou

4

1 reference

8 August 2017

Mark H. Ginsberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14570053

23 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14570053

23 March 2024

publication date

1 October 2003

1 reference

full work available at URL

8 August 2017

http://www.nature.com/articles/nrm1229.pdf

file format

Portable Document Format

1 reference

http://www.nature.com/articles/nrm1229

23 March 2024

1 reference

Nature Reviews Molecular Cell Biology

23 March 2024

published in

1 reference

8 August 2017

4

1 reference

8 August 2017

767-776

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8 August 2017

10

1 reference

https://scigraph.springernature.com/pub.10.1038/nrm1229

8 August 2017

0 references

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C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

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Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins

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Biochemical characterization of the Ras-related GTPases Rit and Rin

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Understanding Ras: 'it ain't over 'til it's over'.

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Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway

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Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase

31 March 2020

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Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail

31 March 2020

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Down-regulation of alpha6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc

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Blockade of focal clustering and active conformation in beta 2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras.

31 March 2020

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The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway

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Distinct Mechanisms of α5β1Integrin Activation by Ha-Ras and R-Ras

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The death effector domain of PEA-15 is involved in its regulation of integrin activation

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PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

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Integrin activation by R-ras.

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R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells

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Regulation of neurite outgrowth by integrin activation.

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The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

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R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras

31 March 2020

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R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras

31 March 2020

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The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function

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Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains

31 March 2020

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

31 March 2020

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

31 March 2020

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3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

31 March 2020

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Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

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Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

31 March 2020

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Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

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Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

31 March 2020

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

31 March 2020

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Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion

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Rap1 signalling: adhering to new models

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Distinct domains of CD98hc regulate integrins and amino acid transport

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Complementation of dominant suppression implicates CD98 in integrin activation.

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CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

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The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

31 March 2020

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Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection

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The Src family kinase Fyn mediates signals induced by TCR antagonists

31 March 2020

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

31 March 2020

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Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

31 March 2020

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Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

31 March 2020

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Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

31 March 2020

1 reference

The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion

31 March 2020

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

31 March 2020

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RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

31 March 2020

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Mechanism of the spatio-temporal regulation of Ras and Rap1.

31 March 2020

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R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

31 March 2020

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Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras

31 March 2020

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Integrin cytoplasmic domains mediate inside-out signal transduction

31 March 2020

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The phosphotyrosine binding-like domain of talin activates integrins

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Talin is essential for integrin function in Drosophila

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Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

31 March 2020

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Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

31 March 2020

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Membrane raft microdomains in chemokine receptor function

31 March 2020

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The role of membrane lipids in regulation of integrin functions.

31 March 2020

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

31 March 2020

1 reference

Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus

31 March 2020

1 reference

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

31 March 2020

1 reference

Carboxyl methylation of Ras-related proteins

31 March 2020

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Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils

31 March 2020

1 reference

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

31 March 2020

1 reference

Transient palmitoylation supports H-Ras membrane binding but only partial biological activity

31 March 2020

1 reference

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

31 March 2020

1 reference

Polylysine domain of K-ras 4B protein is crucial for malignant transformation

31 March 2020

1 reference

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

31 March 2020

1 reference

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

31 March 2020

1 reference

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

31 March 2020

1 reference

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

31 March 2020

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The many faces of Ras: recognition of small GTP-binding proteins

31 March 2020

1 reference

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

31 March 2020

1 reference

Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution

31 March 2020

1 reference

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

31 March 2020

1 reference

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

31 March 2020

1 reference

Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

1 reference

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

31 March 2020

1 reference

R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

31 March 2020

1 reference

Genome sequence of the nematode C. elegans: a platform for investigating biology

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

6

50

75

MH Ginsberg

1991

1 reference

Science's STKE : signal transduction knowledge environment

23 March 2024

29

103

PL9

ML Matter

2001

1 reference

23 March 2024

Identifiers

DOI

10.1038/NRM1229

1 reference

Dimensions Publication ID

8 August 2017

0 references

1 reference