(Q34238051)

31 July 2017

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title

Rap1 signalling: adhering to new models (English)

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31 July 2017

Bos JL

1

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31 July 2017

de Rooij J

series ordinal

2

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31 July 2017

Reedquist KA

series ordinal

3

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31 July 2017

publication date

1 May 2001

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

5

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31 July 2017

page(s)

369-377

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https://scigraph.springernature.com/pub.10.1038/35073073

31 July 2017

exact match

0 references

1 reference

7 January 2021

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

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7 January 2021

Rapid Ca2+-mediated activation of Rap1 in human platelets

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7 January 2021

Cyclic AMP-dependent activation of Rap1b

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7 January 2021

Activation of the Rap1 GTPase by the B cell antigen receptor

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7 January 2021

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

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7 January 2021

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

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7 January 2021

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

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7 January 2021

Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

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7 January 2021

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

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7 January 2021

Activation of R-Ras by Ras-guanine nucleotide-releasing factor

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7 January 2021

Crk activation of JNK via C3G and R-Ras

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7 January 2021

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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7 January 2021

A family of cAMP-binding proteins that directly activate Rap1

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7 January 2021

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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7 January 2021

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

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7 January 2021

Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1

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7 January 2021

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

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7 January 2021

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

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7 January 2021

CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

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7 January 2021

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

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7 January 2021

PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2

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7 January 2021

nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)

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7 January 2021

RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans

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7 January 2021

Identification of a novel beta-catenin-interacting protein

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7 January 2021

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

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7 January 2021

Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells

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7 January 2021

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

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7 January 2021

Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk

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7 January 2021

Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.

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7 January 2021

Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

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7 January 2021

The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

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7 January 2021

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

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7 January 2021

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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7 January 2021

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

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7 January 2021

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

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7 January 2021

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

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7 January 2021

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases

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7 January 2021

Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.

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7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

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7 January 2021

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

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7 January 2021

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

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7 January 2021

Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1

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7 January 2021

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

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7 January 2021

cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway

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7 January 2021

Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.

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7 January 2021

Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein

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7 January 2021

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

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7 January 2021

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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7 January 2021

Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex

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7 January 2021

beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

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7 January 2021

Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase

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7 January 2021

cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons.

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7 January 2021

Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.

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7 January 2021

Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways

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7 January 2021

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

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7 January 2021

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

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7 January 2021

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

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7 January 2021

The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein

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7 January 2021

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

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7 January 2021

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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7 January 2021

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

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7 January 2021

The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme

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7 January 2021

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

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7 January 2021

In vivo interaction of AF-6 with activated Ras and ZO-1

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7 January 2021

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

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7 January 2021

Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion

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7 January 2021

Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

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7 January 2021

The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

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7 January 2021

Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase

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7 January 2021

The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum

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7 January 2021

The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

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7 January 2021

Sequential regulation of the small GTPase Rap1 in human platelets

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7 January 2021

Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts

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7 January 2021

The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases

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7 January 2021

Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia

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7 January 2021

Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae

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7 January 2021

Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site

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7 January 2021

Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective

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7 January 2021

A Candida albicans RAS-related gene (CaRSR1) is involved in budding, cell morphogenesis and hypha development

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7 January 2021

Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium

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7 January 2021

The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination

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7 January 2021

The Rap1 GTPase functions as a regulator of morphogenesis in vivo

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7 January 2021

Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.

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7 January 2021

Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1

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7 January 2021

Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology

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7 January 2021

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7 January 2021

NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway

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7 January 2021

Mitogenic and oncogenic properties of the small G protein Rap1b

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7 January 2021

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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7 January 2021

Identifiers

DOI

10.1038/35073073

1 reference

Dimensions Publication ID

31 July 2017

1042382877

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