(Q36327175)

English

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Bert Vogelstein

6

object named as

Bert Vogelstein

0 references

Philip E. Thompson

object named as

Philip E Thompson

8

0 references

Kenneth W. Kinzler

5

object named as

Kenneth W Kinzler

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Oleg Schmidt-Kittler

4

object named as

Oleg Schmidt-Kittler

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1

object named as

Zhaohua Zheng

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Syazwani I Amran

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jiuxiang Zhu

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Peter R Shepherd

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ian G Jennings

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

1 June 2012

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

444

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

529-535

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Conformational adaptation in drug-target interactions and residence time

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

New phosphatidylinositol 3-kinase inhibitors for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

PI3Kα inhibitors that inhibit metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

The emerging mechanisms of isoform-specific PI3K signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474370

30 September 2017

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120499

21 January 2018

Phosphoinositide-3-kinases (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110alpha

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120499

21 January 2018

Identifiers

10.1042/BJ20120499

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q36327175&oldid=1834110601"