(Q36342610)

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Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia

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scholarly article

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Europe PubMed Central

PMC publication ID

10 December 2017

Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia (English)

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

click chemistry

1 reference

based on heuristic

inferred from title

Giardia lamblia

1 reference

based on heuristic

inferred from title

Karl Barry Sharpless

6

object named as

K Barry Sharpless

1 reference

Europe PubMed Central

10 December 2017

PMC publication ID

Valery V. Fokin

7

object named as

Valery V Fokin

1 reference

Europe PubMed Central

10 December 2017

PMC publication ID

author name string

Wan Jung Kim

1

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Keith A Korthals

2

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Suhua Li

3

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Christine Le

4

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Jarosław Kalisiak

5

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Yukiko Miyamoto

8

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Lars Eckmann

9

1 reference

Europe PubMed Central

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10 December 2017

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publication date

10 April 2017

1 reference

Europe PubMed Central

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10 December 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

10 December 2017

61

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Europe PubMed Central

PMC publication ID

10 December 2017

6

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Drug Resistance in the Microaerophilic Parasite Giardia lamblia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Giardiasis surveillance -- United States, 2011-2012.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Irritable bowel syndrome and chronic fatigue 6 years after giardia infection: a controlled prospective cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Nitazoxanide for the empiric treatment of pediatric infectious diarrhea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Waterborne transmission of protozoan parasites: review of worldwide outbreaks - an update 2004-2010.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Metronidazole is still the drug of choice for treatment of anaerobic infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Antiamoebic drugs for treating amoebic colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Giardiasis: a pharmacotherapy review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Virtual Computational Chemistry Laboratory – Design and Description

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Data mining in bioinformatics using Weka

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Effect of different doses of furazolidone with amoxicillin and omeprazole on eradication of Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Methods for cultivation of luminal parasitic protists of clinical importance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Drug targets and mechanisms of resistance in the anaerobic protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Why metronidazole is active against both bacteria and parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Metronidazole. A therapeutic review and update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Giardia lamblia infections in adult mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells. I. Comparative in vitro cytotoxicity of 27 drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Altered uptake of metronidazole in vitro by stocks of Giardia intestinalis with different drug sensitivities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Induction of metronidazole and furazolidone resistance in Giardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

29 June 2018

Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

The treatment of giardiasis in children: single-dose tinidazole compared with 3 days of nitazoxanide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

On interpretation of well-known topological indices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

DNA breakage due to metronidazole treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

Treatment of patients with refractory giardiasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5444119

22 September 2018

Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/28396548

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28396548

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.02397-16

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 December 2017

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