(Q36343541)

13 August 2017

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title

Lymphocyte calcium signaling from membrane to nucleus (English)

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13 August 2017

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Elena M Gallo

1

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13 August 2017

Kirsten Canté-Barrett

series ordinal

2

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13 August 2017

Gerald R Crabtree

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 January 2006

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13 August 2017

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13 August 2017

7

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13 August 2017

25-32

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13 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ni1295

13 August 2017

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cites work

Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells

1 reference

Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells

21 January 2018

1 reference

Mitochondrial regulation of store-operated calcium signaling in T lymphocytes

21 January 2018

1 reference

Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes

21 January 2018

1 reference

Potassium and calcium channels in lymphocytes

21 January 2018

1 reference

The versatility and universality of calcium signalling

21 January 2018

1 reference

Calcium signaling mechanisms in T lymphocytes

21 January 2018

1 reference

Ca2+ signals and T lymphocytes; "New mechanisms and functions in Ca2+ signalling".

21 January 2018

1 reference

T cell receptor signaling: beyond complex complexes

21 January 2018

1 reference

Phospholipase C-gamma is required for agonist-induced Ca2+ entry

21 January 2018

1 reference

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain

21 January 2018

1 reference

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry

21 January 2018

1 reference

Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.

21 January 2018

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The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.

21 January 2018

1 reference

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

21 January 2018

1 reference

LAB: a new membrane-associated adaptor molecule in B cell activation

21 January 2018

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Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

21 January 2018

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Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.

21 January 2018

1 reference

Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL

21 January 2018

1 reference

Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding

21 January 2018

1 reference

The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB

21 January 2018

1 reference

The Actin Cytoskeleton and Lymphocyte Activation

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Cytoskeletal remodeling in lymphocyte activation

21 January 2018

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

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T cell receptor signaling precedes immunological synapse formation

21 January 2018

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

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Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration

21 January 2018

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Actin depolymerization transduces the strength of B-cell receptor stimulation

21 January 2018

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Effect of cytochalasins on F-actin and morphology of Ehrlich ascites tumor cells.

21 January 2018

1 reference

Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

21 January 2018

1 reference

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

21 January 2018

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The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.

21 January 2018

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Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production

21 January 2018

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A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization

21 January 2018

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Vav-family proteins in T-cell signalling

21 January 2018

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B-cell development and antigen receptor signalling

21 January 2018

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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

21 January 2018

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The regulation of actin remodeling during T-cell-APC conjugate formation

21 January 2018

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SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

21 January 2018

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

21 January 2018

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Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.

21 January 2018

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Depletion of intracellular calcium stores activates a calcium current in mast cells

21 January 2018

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Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores

21 January 2018

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Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

21 January 2018

1 reference

Isolation of mutant T lymphocytes with defects in capacitative calcium entry

21 January 2018

1 reference

Gene regulation mediated by calcium signals in T lymphocytes

21 January 2018

1 reference

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

21 January 2018

1 reference

STIM1, an essential and conserved component of store-operated Ca2+ channel function

21 January 2018

1 reference

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

21 January 2018

1 reference

Nomenclature of voltage-gated calcium channels.

21 January 2018

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Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

21 January 2018

1 reference

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

21 January 2018

1 reference

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes

21 January 2018

1 reference

Lymphocyte calcium signaling involves dihydropyridine-sensitive L-type calcium channels: facts and controversies

21 January 2018

1 reference

Voltage-gated potassium channels are required for human T lymphocyte activation

21 January 2018

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K+ channels as targets for specific immunomodulation

21 January 2018

1 reference

A non-voltage-gated calcium channel with L-type characteristics activated by B cell receptor ligation

21 January 2018

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Identification and functional characterization of voltage-dependent calcium channels in T lymphocytes

21 January 2018

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Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

21 January 2018

1 reference

The TRP ion channel family.

21 January 2018

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TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes

21 January 2018

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Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3.

21 January 2018

1 reference

Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells

21 January 2018

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Regulation of TRP channels via lipid second messengers.

21 January 2018

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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

21 January 2018

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Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C.

21 January 2018

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CaT1 and the calcium release-activated calcium channel manifest distinct pore properties.

21 January 2018

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Identification and characterization of the murine TRPM4 channel

21 January 2018

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TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

21 January 2018

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Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform

21 January 2018

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Voltage dependence of the Ca2+-activated cation channel TRPM4

21 January 2018

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TRPM4 regulates calcium oscillations after T cell activation

21 January 2018

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Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.

21 January 2018

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Early signal transduction by the antigen receptor without commitment to T cell activation

21 January 2018

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Polarity of T cell shape, motility, and sensitivity to antigen

21 January 2018

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A single class II myosin modulates T cell motility and stopping, but not synapse formation

21 January 2018

1 reference

Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes.

21 January 2018

1 reference

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

21 January 2018

1 reference

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice

21 January 2018

1 reference

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.

21 January 2018

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Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity

21 January 2018

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Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes

21 January 2018

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Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism

21 January 2018

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Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

21 January 2018

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

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Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

21 January 2018

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Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing

21 January 2018

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Ca2+ signaling modulates cytolytic T lymphocyte effector functions

21 January 2018

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T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

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Dancing to the tune of chemokines

21 January 2018

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

21 January 2018

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Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines.

21 January 2018

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Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs

21 January 2018

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Protein kinase C and beyond

21 January 2018

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Differential activation of transcription factors induced by Ca2+ response amplitude and duration

21 January 2018

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Calcium oscillations increase the efficiency and specificity of gene expression

21 January 2018

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Calcium oscillations in T-cells: mechanisms and consequences for gene expression

21 January 2018

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Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

21 January 2018

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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

21 January 2018

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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation

21 January 2018

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Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2

21 January 2018

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Calmodulin trapping by calcium-calmodulin-dependent protein kinase

21 January 2018

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The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription

21 January 2018

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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

21 January 2018

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Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex

21 January 2018

1 reference

A novel protein phosphatase that dephosphorylates and regulates Ca2+/calmodulin-dependent protein kinase II.

21 January 2018

1 reference

Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase

21 January 2018

1 reference

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

21 January 2018

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

21 January 2018

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

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Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

21 January 2018

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Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

21 January 2018

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Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

21 January 2018

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Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.

21 January 2018

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A viral mechanism for inhibition of the cellular phosphatase calcineurin.

21 January 2018

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Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation

21 January 2018

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NFAT signaling: choreographing the social lives of cells

21 January 2018

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Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.

21 January 2018

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Transcription factors of the NFAT family: regulation and function

21 January 2018

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NFAT proteins: key regulators of T-cell development and function

21 January 2018

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Contingent genetic regulatory events in T lymphocyte activation

21 January 2018

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Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

21 January 2018

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Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

21 January 2018

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Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation

21 January 2018

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CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

21 January 2018

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

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The role of CTLA-4 in the regulation and initiation of T-cell responses

21 January 2018

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Nf1 has an essential role in endothelial cells

21 January 2018

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Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

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Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones

21 January 2018

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

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Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

21 January 2018

1 reference

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

21 January 2018

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Cain, a novel physiologic protein inhibitor of calcineurin

21 January 2018

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Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

21 January 2018

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

21 January 2018

1 reference

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

21 January 2018

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CaT1 manifests the pore properties of the calcium-release-activated calcium channel

21 January 2018

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The role of mitochondria in the regulation of calcium influx into Jurkat cells

21 January 2018

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7 January 2021

Vav1: a key signal transducer downstream of the TCR

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7 January 2021

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

1 reference

7 January 2021

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

1 reference

7 January 2021

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

1 reference

7 January 2021

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

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7 January 2021

Anti-Ig-induced calcium influx in rat B lymphocytes mediated by cGMP through a dihydropyridine-sensitive channel

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7 January 2021

Molecular characterization of L-type calcium channel splice variants expressed in human T lymphocytes

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7 January 2021

Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.

1 reference

7 January 2021

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1 reference

7 January 2021

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

1 reference

7 January 2021

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1295

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Dimensions Publication ID

13 August 2017

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