(Q36345737)

13 August 2017

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title

ADPKD: molecular characterization and quest for treatment (English)

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13 August 2017

1

Shigeo Horie

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13 August 2017

publication date

1 December 2005

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Clinical and experimental nephrology

13 August 2017

published in

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13 August 2017

volume

9

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13 August 2017

issue

4

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13 August 2017

page(s)

282-291

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Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

13 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS10157-005-0367-6

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage

21 January 2018

1 reference

12 December 2020

Polycystin 1 is required for the structural integrity of blood vessels

1 reference

12 December 2020

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1 reference

12 December 2020

Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells

1 reference

12 December 2020

Left ventricular hypertrophy in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Autosomal dominant polycystic kidney disease: clues to pathogenesis

1 reference

12 December 2020

AVP inhibits EGF-stimulated MAP kinase cascade in Madin-Darby canine kidney cells

1 reference

12 December 2020

Polycystic kidney disease: In danger of being X-rated?

1 reference

12 December 2020

Distribution and developmentally regulated expression of murine polycystin

1 reference

12 December 2020

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

1 reference

12 December 2020

Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

1 reference

12 December 2020

Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1.

1 reference

12 December 2020

1992 Homer Smith Award. Fluid secretion, cellular proliferation, and the pathogenesis of renal epithelial cysts.

1 reference

12 December 2020

Chloride and fluid secretion by cultured human polycystic kidney cells

1 reference

12 December 2020

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

1 reference

12 December 2020

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

1 reference

12 December 2020

Association of eNOS Glu298Asp polymorphism with end-stage renal disease

1 reference

12 December 2020

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

1 reference

12 December 2020

Genetics and pathogenesis of polycystic kidney disease.

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12 December 2020

Mutation analysis of the entire PKD1 gene: genetic and diagnostic implications

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12 December 2020

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

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12 December 2020

Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein

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12 December 2020

cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells.

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12 December 2020

Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats.

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12 December 2020

Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease

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12 December 2020

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

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12 December 2020

Vascular expression of polycystin-2.

1 reference

12 December 2020

Renal, cardiovascular and hormonal characteristics of young adults with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Pharmacologic control of angiotensin II ameliorates renal disease while reducing renal TGF-beta in experimental mesangioproliferative glomerulonephritis

1 reference

12 December 2020

Hepatocyte growth factor and the kidney

1 reference

12 December 2020

Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group

1 reference

12 December 2020

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

1 reference

12 December 2020

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

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12 December 2020

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

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12 December 2020

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

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12 December 2020

Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease

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12 December 2020

Polycystins: from mechanosensation to gene regulation

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12 December 2020

Pathogenesis of hypertension in autosomal dominant polycystic kidney disease

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12 December 2020

A spectrum of mutations in the polycystic kidney disease-2 (PKD2) gene from eight Canadian kindreds

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12 December 2020

Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides

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12 December 2020

Cerebral aneurysms in patients with autosomal dominant polycystic kidney disease--to screen, to clip, to coil?

1 reference

12 December 2020

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

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12 December 2020

The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease

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12 December 2020

Identification and characterization of polycystin-2, the PKD2 gene product

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12 December 2020

The polycystic kidney disease 1 gene product modulates Wnt signaling

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12 December 2020

Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298.

1 reference

12 December 2020

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

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12 December 2020

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

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12 December 2020

Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells

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12 December 2020

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

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12 December 2020

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

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12 December 2020

The Position of the Polycystic Kidney Disease 1 (PKD1) Gene Mutation Correlates with the Severity of Renal Disease

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12 December 2020

Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype.

1 reference

12 December 2020

Polycystic kidney disease

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12 December 2020

Mediation of renal cyst formation by hepatocyte growth factor

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12 December 2020

In vitro fluid secretion by epithelium from polycystic kidneys

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12 December 2020

Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor.

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12 December 2020

How to make tubes: signaling by the Met receptor tyrosine kinase

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12 December 2020

Extrarenal manifestations of autosomal dominant polycystic kidney disease

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12 December 2020

Modifier effect of ENOS in autosomal dominant polycystic kidney disease.

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12 December 2020

Terminal differentiation of human breast cancer through PPAR gamma

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12 December 2020

Glomerulosclerosis and renal cysts in mice transgenic for the early region of SV40

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12 December 2020

The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease

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12 December 2020

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death

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12 December 2020

Identification and localization of polycystin, the PKD1 gene product

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12 December 2020

Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells

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12 December 2020

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2

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12 December 2020

Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

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12 December 2020

Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease

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12 December 2020

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

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12 December 2020

The L-arginine-nitric oxide pathway

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12 December 2020

Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis

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12 December 2020

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant

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12 December 2020

Polycystin: new aspects of structure, function, and regulation

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12 December 2020

Prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease in Japan.

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12 December 2020

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

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12 December 2020

Renal epithelial fluid secretion and cyst growth: the role of cyclic AMP

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12 December 2020

Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease.

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12 December 2020

Functional polycystin-1 expression is developmentally regulated during epithelial morphogenesis in vitro: downregulation and loss of membrane localization during cystogenesis

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12 December 2020

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

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12 December 2020

Calcium channel blocker versus angiotensin II receptor blocker in autosomal dominant polycystic kidney disease

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12 December 2020

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

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12 December 2020

A complete mutation screen of the ADPKD genes by DHPLC

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12 December 2020

Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts

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12 December 2020

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

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12 December 2020

Clinical aspects of polycystic kidney disease

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12 December 2020

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

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12 December 2020

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

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12 December 2020

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

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12 December 2020

Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis.

1 reference

12 December 2020

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

1 reference

12 December 2020

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

1 reference

12 December 2020

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium

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12 December 2020

Polycystin-2 is an intracellular calcium release channel

1 reference

12 December 2020

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

1 reference

12 December 2020

Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.

1 reference

12 December 2020

Mutation analysis of the entire replicated portion of PKD1 using genomic DNA samples

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12 December 2020

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys

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12 December 2020

Homologues to the first gene for autosomal dominant polycystic kidney disease are pseudogenes

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12 December 2020

Polycystin-1 interacts with intermediate filaments

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12 December 2020

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

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12 December 2020

Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.

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12 December 2020

A road to kidney tubules via the Wnt pathway

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12 December 2020

Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism

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12 December 2020

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

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12 December 2020

Molecular cloning and expression of human hepatocyte growth factor

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12 December 2020

PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

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12 December 2020

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo

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12 December 2020

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

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12 December 2020

c-myc as an inducer of polycystic kidney disease in transgenic mice

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12 December 2020

10.1007/S10157-005-0367-6

Identifiers

DOI

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13 August 2017

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