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PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
title
PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
main subject
Huntington's disease
0 references
author
Thomas Rival
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
Jean-Charles Liévens
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
author name string
B Khalil
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
N El Fissi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
A Aouane
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
M-J Cabirol-Pol
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
publication date
22 January 2015
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
published in
Cell Death and Disease
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
page(s)
e1617
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
copyright license
Creative Commons Attribution 4.0 International
start time
1 January 2015
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Electron microscopic analysis of a spherical mitochondrial structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Effects of overexpression of huntingtin proteins on mitochondrial integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
30 September 2017
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
29 June 2018
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
29 June 2018
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
29 June 2018
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
Mitochondrial defect in Huntington's disease caudate nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669776
retrieved
22 September 2018
Identifiers
DOI
10.1038/CDDIS.2014.581
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PMCID
4669776
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PubMed ID
25611391
1 reference
stated in
Europe PubMed Central
PMCID
4669776
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25611391%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
ResearchGate publication ID
271331478
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