(Q36348873)

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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

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13 August 2017

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages (English)

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Europe PubMed Central

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13 August 2017

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Peter Libby

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13 August 2017

Gökhan Hotamışlıgil

14

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Gokhan S Hotamisligil

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13 August 2017

9

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Cong-Lin Liu

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13 August 2017

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author name string

Yi Zhou

1

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13 August 2017

Xueqing Yu

2

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13 August 2017

Huimei Chen

3

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13 August 2017

Sara Sjöberg

4

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13 August 2017

Joséphine Roux

5

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13 August 2017

Lijun Zhang

6

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13 August 2017

Al-Habib Ivoulsou

7

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13 August 2017

Farid Bensaid

8

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13 August 2017

Jian Liu

10

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13 August 2017

Joan Tordjman

11

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13 August 2017

Karine Clement

12

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13 August 2017

Chih-Hao Lee

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13 August 2017

Guo-Ping Shi

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13 August 2017

publication date

14 October 2015

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13 August 2017

Cell Metabolism

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13 August 2017

22

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13 August 2017

6

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13 August 2017

1045-1058

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13 August 2017

Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects.

1 reference

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30 September 2017

Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors

1 reference

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30 September 2017

Investigation of macrophage polarization using bone marrow derived macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Immunological goings-on in visceral adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression.

1 reference

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30 September 2017

Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Direct control of hepatic glucose production by interleukin-13 in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

New models for analyzing mast cell functions in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

At the crossroad of T cells, adipose tissue, and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Macrophage-mediated inflammation in metabolic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Krüppel-like factor 4 regulates macrophage polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Inflammatory mechanisms in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Distinguishing mast cell and granulocyte differentiation at the single-cell level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Normalization of obesity-associated insulin resistance through immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Human leptin stimulates proliferation and activation of human circulating monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Effect of ketotifen in obese patients with type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

30 September 2017

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

29 June 2018

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

29 June 2018

Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

29 June 2018

Determinants of serum tryptase in a general population: the relationship of serum tryptase to obesity and asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Leptin as a uremic toxin interferes with neutrophil chemotaxis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Bone marrow mast cell morphologic features and hematopoietic dyspoiesis in systemic mast cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670585

22 September 2018

Neurogenic inflammation in allergen-challenged obese mice: a missing link in the obesity-asthma association?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased neutrophils and megakaryocytes in anemic mice of genotypeW/Wv

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin Promotes Differentiation and Survival of Human Dendritic Cells and Licenses Them for Th1 Priming

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human leptin enhances activation and proliferation of human circulating T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A key role of leptin in the control of regulatory T cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26481668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CMET.2015.09.013

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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