(Q36359489)

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The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

prostate cancer

1 reference

based on heuristic

inferred from title

author name string

Heather Venant

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Mehrdad Rahmaniyan

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

E Ellen Jones

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ping Lu

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Michael B Lilly

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Elizabeth Garrett-Mayer

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Richard R Drake

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jacqueline M Kraveka

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Charles D Smith

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Christina Voelkel-Johnson

10

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

publication date

22 October 2015

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Europe PubMed Central

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13 August 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

14

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2744-2752

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4674301/fullTextXML

based on heuristic

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ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer

1 reference

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A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

1 reference

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Advanced prostate cancer - patient survival and potential impact of enzalutamide and other emerging therapies

1 reference

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1 reference

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Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival

1 reference

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MALDI imaging mass spectrometry profiling of proteins and lipids in clear cell renal cell carcinoma

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1 reference

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Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

1 reference

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Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640.

1 reference

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Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation

1 reference

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Roles, regulation and inhibitors of sphingosine kinase 2.

1 reference

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30 September 2017

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1 reference

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The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

1 reference

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Sphingolipids in apoptosis

1 reference

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30 September 2017

Characterization of isoenzyme-selective inhibitors of human sphingosine kinases

1 reference

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30 September 2017

Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer

1 reference

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Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats

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Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors

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Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer

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Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion

1 reference

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Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

1 reference

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Normalization in MALDI-TOF imaging datasets of proteins: practical considerations

1 reference

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Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.

1 reference

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Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

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Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

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Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

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Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640

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Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

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Combined anticancer effects of sphingosine kinase inhibitors and sorafenib

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Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

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Ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cells

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Myc confers androgen-independent prostate cancer cell growth

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.

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Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.

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Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease

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22 September 2018

Identifiers

10.1158/1535-7163.MCT-15-0279

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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