(Q36365264)

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A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans

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Europe PubMed Central

PMC publication ID

13 August 2017

A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Caenorhabditis elegans

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author name string

Shaarika Sarasija

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Kenneth R Norman

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

23 October 2015

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

201

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1453-1466

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans

1 reference

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C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair

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Regulation of the innate immune response by fibronectin: synergism between the III-1 and EDA domains

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Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis

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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

1 reference

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Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

1 reference

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Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

1 reference

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Mitochondria-associated ER membranes in Alzheimer disease

1 reference

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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

1 reference

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From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease.

1 reference

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Notch and the awesome power of genetics

1 reference

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Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans

1 reference

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Mitochondrial Ca(2+) and neurodegeneration

1 reference

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Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

1 reference

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30 September 2017

Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation

1 reference

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30 September 2017

A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans

1 reference

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30 September 2017

An expanded palette of genetically encoded Ca²⁺ indicators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

30 September 2017

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

1 reference

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30 September 2017

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

1 reference

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30 September 2017

The Alzheimer's disease mitochondrial cascade hypothesis

1 reference

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30 September 2017

The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

30 September 2017

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

30 September 2017

Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans

1 reference

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30 September 2017

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

1 reference

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30 September 2017

Optogenetic analysis of synaptic function

1 reference

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30 September 2017

The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias

1 reference

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

1 reference

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30 September 2017

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

1 reference

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30 September 2017

Substrate specificity of gamma-secretase and other intramembrane proteases

1 reference

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30 September 2017

Amyloid plaque imaging in vivo: current achievement and future prospects.

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30 September 2017

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

1 reference

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Notch signaling in the C. elegans embryo

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1 reference

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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

1 reference

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30 September 2017

UNC-1 regulates gap junctions important to locomotion in C. elegans

1 reference

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A hundred years of Alzheimer's disease research

1 reference

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30 September 2017

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

1 reference

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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30 September 2017

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

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1 reference

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1 reference

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1 reference

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30 September 2017

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

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30 September 2017

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

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HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

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30 September 2017

Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans

1 reference

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

1 reference

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1 reference

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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1 reference

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1 reference

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

30 September 2017

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

1 reference

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1 reference

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28 June 2018

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

28 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

28 June 2018

The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

28 June 2018

Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

1 reference

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Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy

1 reference

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22 September 2018

Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

22 September 2018

Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.

1 reference

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Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease

1 reference

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22 September 2018

Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

22 September 2018

Identification of new presenilin gene mutations in early-onset familial Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

22 September 2018

The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities

1 reference

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22 September 2018

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676538

22 September 2018

Mitochondrial metabolism of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/26500256

12 December 2020

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https://pubmed.ncbi.nlm.nih.gov/26500256

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Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/26500256

12 December 2020

based on heuristic

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Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/26500256

12 December 2020

based on heuristic

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Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26500256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/26500256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postoperative MRI appearance after transsphenoidal pituitary tumor resection

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https://pubmed.ncbi.nlm.nih.gov/26500256

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Identifiers

10.1534/GENETICS.115.182808

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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