(Q38029575)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Kristina Leuner

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Walter E Müller

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

1 reference

26 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

published in

Molecular Neurobiology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

186-193

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12035-012-8307-4

9 February 2020

exact match

0 references

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The role of mitochondria in reactive oxygen species metabolism and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Ageing and neuronal vulnerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Regulation of autophagy by ROS: physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Enhanced ROS-generation in lymphocytes from Alzheimer's patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Regional difference of ROS generation, lipid peroxidation, and antioxidant enzyme activity in rat brain and their dietary modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Gene regulation and DNA damage in the ageing human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Proteome alterations in rat mitochondria caused by aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Brain aging, Alzheimer's disease, and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Interaction between α-synuclein and other proteins in neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial dysfunction in mouse trisomy 16 brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The neuropathology of probable Alzheimer disease and mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial disorders, cognitive impairment and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Mitochondrial dementia: a sporadic case of progressive cognitive and behavioral decline with hearing loss due to the rare m.3291T>C MELAS mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8307-4

Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria

21 January 2018

1 reference

12 December 2020

Cognitive impairment and increased Aβ levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2).

1 reference

12 December 2020

Mitochondria-ros crosstalk in the control of cell death and aging

1 reference

12 December 2020

Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice

1 reference

12 December 2020

Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

1 reference

12 December 2020

Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

1 reference

12 December 2020

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

1 reference

12 December 2020

Amyloid-Beta interaction with mitochondria

1 reference

12 December 2020

Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8

1 reference

12 December 2020

Control of OXPHOS efficiency by complex I in brain mitochondria

1 reference

12 December 2020

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

1 reference

12 December 2020

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

1 reference

12 December 2020

Mitochondrial metabolism of reactive oxygen species.

1 reference

12 December 2020

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway

1 reference

12 December 2020