(Q34440371)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

0 references

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Michel Bernier

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Jaewon Lee

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Dong-Gyu Jo

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

19

Mark P Mattson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

William R. Markesbery

18

object named as

William R Markesbery

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

A-Ryeong Gwon

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Jong-Sung Park

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Thiruma V Arumugam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Yong-Kook Kwon

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Sic L Chan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Seol-Hee Kim

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Sang-Ha Baik

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Sunghee Yang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Young-Kwang Yun

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Yuri Choi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Saerom Kim

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Dong-Hoon Hyun

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Aiwu Cheng

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Charles E Dann

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

publication date

9 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

Aging Cell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

559-568

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

Oxidative stress in Alzheimer disease: a possibility for prevention

25 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Pathways towards and away from Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Purification and characterization of the human gamma-secretase complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Pro-apoptotic function of calsenilin/DREAM/KChIP3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Neuropathological criteria for the diagnosis of Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Oxidative stress hypothesis in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

6 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Overexpression of calsenilin enhances gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Oxidative stress increases expression and activity of BACE in NT2 neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Neuroprotective actions of a histidine analogue in models of ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00817.X

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217088

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22404891

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22404891

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1474-9726.2012.00817.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

22404891

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22404891%20AND%20SRC:MED&resulttype=core&format=json