(Q40014779)

16 September 2017

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. (English)

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16 September 2017

4

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16 September 2017

Virginie Buggia-Prevot

series ordinal

1

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16 September 2017

Jean Sevalle

series ordinal

2

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16 September 2017

Steffen Rossner

series ordinal

3

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16 September 2017

language of work or name

English

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publication date

8 February 2008

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

15

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16 September 2017

10037-10047

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Alzheimer's disease: the amyloid cascade hypothesis

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Identification of the role of presenilins beyond Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Involvement of presenilins in cell-survival signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Cloning and expression of the rat BACE1 promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Inhibition of Abeta production by NF-kappaB inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Peptidases, proteases and amyloid beta-peptide catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706579200

21 January 2018

Identifiers

DOI

10.1074/JBC.M706579200

1 reference

16 September 2017

1 reference