(Q36368169)

13 August 2017

Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase (English)

1 reference

13 August 2017

Pramod Kumar Yadav

1

1 reference

13 August 2017

Peter Xie

series ordinal

2

1 reference

13 August 2017

Ruma Banerjee

series ordinal

3

1 reference

13 August 2017

language of work or name

English

0 references

publication date

12 September 2012

1 reference

Journal of Biological Chemistry

13 August 2017

1 reference

13 August 2017

287

1 reference

13 August 2017

45

1 reference

13 August 2017

37611-37620

1 reference

Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

PLP-dependent H(2)S biogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Redox biochemistry of hydrogen sulfide

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

The heme of cystathionine beta-synthase likely undergoes a thermally induced redox-mediated ligand switch

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Reaction mechanism and regulation of cystathionine beta-synthase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Impaired heme binding and aggregation of mutant cystathionine beta-synthase subunits in homocystinuria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Cystathionine beta-synthase mutations in homocystinuria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Correction of disease-causing CBS mutations in yeast

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Dynamics of carbon monoxide binding to CooA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Characterization of tryptophan and coenzyme luminescence in tryptophan synthase from Salmonella typhimurium

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488039

Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.414706

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.414706

Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.414706

The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.414706

Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.414706

Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies

21 January 2018

1 reference

12 December 2020

Activation of cystathionine synthase by adenosylmethionine and adenosylethionine

1 reference

12 December 2020

Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity

1 reference

12 December 2020

Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase

1 reference

12 December 2020

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

12 December 2020

Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.414706

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

22977242

1 reference