(Q37409372)

English

Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.

scientific article published on 22 January 2009

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

4

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21 January 2020

author name string

Sangita Singh

1

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21 January 2020

Peter Madzelan

2

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21 January 2020

Jay Stasser

3

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21 January 2020

Donald Becker

5

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21 January 2020

Thomas G Spiro

6

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21 January 2020

James Penner-Hahn

7

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21 January 2020

Ruma Banerjee

8

1 reference

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21 January 2020

publication date

22 January 2009

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Europe PubMed Central

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21 January 2020

Journal of Inorganic Biochemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

103

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21 January 2020

5

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21 January 2020

689-697

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21 January 2020

Allosteric regulation and catalysis emerge via a common route.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Allosteric cooperativity in protein kinase A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Dynamics of carbon monoxide binding to cystathionine beta-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

The heme of cystathionine beta-synthase likely undergoes a thermally induced redox-mediated ligand switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Redox properties and coordination structure of the heme in the co-sensing transcriptional activator CooA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Cystathionine beta-synthase mutations in homocystinuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Correction of disease-causing CBS mutations in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

6 September 2017

The transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

14 September 2017

Unusual heme iron-lipid acyl chain coordination in Escherichia coli flavohemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

14 September 2017

Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

28 September 2017

Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

26 June 2018

Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

26 June 2018

Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Expression study of mutant cystathionine beta-synthase found in Japanese patients with homocystinuria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

A method for normalization of X-ray absorption spectra.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772092

2 September 2018

Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox-controlled Ligand Exchange of the Heme in the CO-sensing Transcriptional Activator CooA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermodynamic properties of oxidation-reduction reactions of bacterial, microsomal, and mitochondrial cytochromes P-450: an entropy-enthalpy compensation effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electronic absorption, EPR, and resonance raman spectroscopy of CooA, a CO-sensing transcription activator from R. rubrum, reveals a five-coordinate NO-heme

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Titanium (III) citrate as a nontoxic oxidation-reduction buffering system for the culture of obligate anaerobes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19232736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JINORGBIO.2009.01.009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19232736%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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