(Q36372544)

13 August 2017

1 reference

title

CD45: all is not yet crystal clear (English)

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13 August 2017

Nick Holmes

1

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13 August 2017

publication date

1 February 2006

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13 August 2017

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13 August 2017

volume

117

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13 August 2017

issue

2

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13 August 2017

page(s)

145-155

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CD45: a critical regulator of signaling thresholds in immune cells

13 August 2017

cites work

1 reference

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21 January 2018

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Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

21 January 2018

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The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45.

21 January 2018

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Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

21 January 2018

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Structural study of the sugar chains of human leukocyte common antigen CD45.

21 January 2018

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Crystal structure of the tandem phosphatase domains of RPTP LAR

21 January 2018

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Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization

21 January 2018

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The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region

21 January 2018

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Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation

21 January 2018

1 reference

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Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue.

21 January 2018

1 reference

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Organization and expression of thirteen alternatively spliced exons in catfish CD45 homologs.

21 January 2018

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Expression of CD45 isoforms lacking exons 7, 8 and 10.

21 January 2018

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CD45 isoforms in T cell signalling and development

21 January 2018

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A novel CD45 transcript involving the alternative splicing of a new exon is widely distributed in lymphoid tissues.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice

21 January 2018

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A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Sweet 'n' sour: the impact of differential glycosylation on T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Molecular basis of antigenic differences between the RT7 alleles of rat CD45.

21 January 2018

1 reference

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The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A deletion in the gene encoding the CD45 antigen in a patient with SCID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Comparative analysis of CD45 proteins in primate context: owl monkeys vs humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Disease associations and altered immune function in CD45 138G variant carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 (PTPRC) as a candidate gene in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Dynamic regulation of Src-family kinases by CD45 in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Lyn tyrosine kinase: accentuating the positive and the negative

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1+ T cells in CD45-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Disruption of lymphocyte function and signaling in CD45-associated protein-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phosphoacceptor site for casein kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Protein Explorer: easy yet powerful macromolecular visualization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Membrane domains and the immunological synapse: keeping T cells resting and ready.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Comparison of CD45 extracellular domain sequences from divergent vertebrate species suggests the conservation of three fibronectin type III domains

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Differential requirements of CD45 for lymphocyte development and function

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

A point mutation in the human CD45 gene associated with defective splicing of exon A.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Specific CD45 isoforms differentially regulate T cell receptor signaling

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Visualisation by low-angle shadowing of the leucocyte-common antigen. A major cell surface glycoprotein of lymphocytes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Developmental expression of CD45 alternate exons in murine T cells. Evidence of additional alternate exon use

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Comparison of Mouse Ly5aand Ly5bLeucocyte Common Antigen Alleles

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782222

A point mutation in PTPRC is associated with the development of multiple sclerosis

21 September 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02265.X

Domain organization of the extracellular region of CD45

21 January 2018

1 reference

12 December 2020

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

1 reference

12 December 2020

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection

1 reference

12 December 2020

CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

1 reference

12 December 2020

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45

1 reference

12 December 2020

Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin 2 secretion and activation signal pathways involving Vav in T cells

1 reference

12 December 2020

Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22

1 reference

12 December 2020

The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo

1 reference

12 December 2020

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes

1 reference

12 December 2020

10.1111/J.1365-2567.2005.02265.X

Identifiers

DOI

1 reference

13 August 2017

0 references

1 reference