(Q36378403)

13 August 2017

Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study (English)

1 reference

13 August 2017

phase I clinical trial

0 references

1 reference

Mehmet Kocak

7

0 references

Maryam Fouladi

2

object named as

Maryam Fouladi

1 reference

13 August 2017

10

Sridharan Gururangan

1 reference

13 August 2017

12

Susan M Blaney

1 reference

13 August 2017

14

Larry E Kun

1 reference

13 August 2017

5

Clinton F Stewart

1 reference

13 August 2017

8

Arzu Onar-Thomas

1 reference

13 August 2017

11

Roger J Packer

1 reference

13 August 2017

13

Amar Gajjar

1 reference

13 August 2017

16

Richard J Gilbertson

1 reference

13 August 2017

Lindsey M Hoffman

1

1 reference

13 August 2017

James Olson

3

1 reference

13 August 2017

Vinay M Daryani

4

1 reference

13 August 2017

Cynthia Wetmore

6

1 reference

13 August 2017

Lars Wagner

9

1 reference

13 August 2017

James M Boyett

15

1 reference

13 August 2017

1 May 2015

1 reference

13 August 2017

Child's Nervous System

1 reference

13 August 2017

31

1 reference

13 August 2017

8

1 reference

13 August 2017

1283-1289

1 reference

Inhibition of notch signaling in combination with Paclitaxel reduces platinum-resistant ovarian tumor growth

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Three-dimensional structure of human γ-secretase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Identification of druggable cancer driver genes amplified across TCGA datasets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

A phase I trial of MK-2206 in children with refractory malignancies: a Children's Oncology Group study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Dissecting the genomic complexity underlying medulloblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Radial glia cells are candidate stem cells of ependymoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Meningioma transcript profiles reveal deregulated Notch signaling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Notch receptors in human choroid plexus tumors

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Phase I study of everolimus in pediatric patients with refractory solid tumors

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681692

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25930724

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Shortening the timeline of pediatric phase I trials: the rolling six design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25930724

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25930724

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00381-015-2725-3

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

25930724

1 reference