(Q37820099)

23 August 2017

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title

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (English)

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23 August 2017

main subject

neoplastic stem cells

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Naoko Takebe

1

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23 August 2017

Pamela J Harris

series ordinal

2

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23 August 2017

Ronald Q Warren

series ordinal

3

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23 August 2017

S Percy Ivy

series ordinal

4

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23 August 2017

language of work or name

English

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publication date

14 December 2010

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Nature Reviews Clinical Oncology

23 August 2017

published in

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23 August 2017

volume

8

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23 August 2017

issue

2

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23 August 2017

page(s)

97-106

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Stem cell concepts renew cancer research

23 August 2017

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Prospective identification of tumorigenic breast cancer cells

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Identification of human brain tumour initiating cells

21 January 2018

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Phenotypic characterization of human colorectal cancer stem cells

21 January 2018

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

21 January 2018

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Identification and expansion of human colon-cancer-initiating cells

21 January 2018

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Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

21 January 2018

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

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Identification of pancreatic cancer stem cells

21 January 2018

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EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

21 January 2018

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Identification of cells initiating human melanomas

21 January 2018

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Significance of CD90+ cancer stem cells in human liver cancer

21 January 2018

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Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

21 January 2018

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Identification and characterization of ovarian cancer-initiating cells from primary human tumors

21 January 2018

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A luminal epithelial stem cell that is a cell of origin for prostate cancer

21 January 2018

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Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

21 January 2018

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Identification of cancer stem cells in Ewing's sarcoma

21 January 2018

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Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

21 January 2018

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 January 2018

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Stem cells, cancer, and cancer stem cells

21 January 2018

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

21 January 2018

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Notch signaling: cell fate control and signal integration in development

21 January 2018

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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 January 2018

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Notch signalling regulates stem cell numbers in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Highly conserved O-fucose sites have distinct effects on Notch1 function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Structural basis for autoinhibition of Notch

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Rational targeting of Notch signaling in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Dosage-sensitive requirement for mouse Dll4 in artery development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

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The Gli code: an information nexus regulating cell fate, stemness and cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

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Targeting the hedgehog signaling pathway with small molecules

21 January 2018

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A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Phase I and pharmacokinetic study of lapatinib and docetaxel in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

A dedicated Wnt secretion factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

The Frizzled family of unconventional G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Identification of a specific inhibitor of the dishevelled PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Epithelial-mesenchymal transitions in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

E-cadherin/catenin/cytoskeleton complex: a regulator of cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

P-glycoprotein: from genomics to mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Association of reactive oxygen species levels and radioresistance in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

A direct cross-talk between interferon-gamma and sonic hedgehog signaling that leads to the proliferation of neuronal precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Intersection of signal transduction pathways and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Cross-talk between Notch and EGFR signaling in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Notch-1 regulates transcription of the epidermal growth factor receptor through p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Signaling cross-talk between TGF-beta/BMP and other pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Pancreatic cancer stem cells: fact or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

The hedgehog pathway as a therapeutic target for treatment of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Celecoxib for the prevention of colorectal adenomatous polyps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

A protein knockdown strategy to study the function of beta-catenin in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Targeted degradation of beta-catenin by chimeric F-box fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Looking ahead in cancer stem cell research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Targeting the Hedgehog pathway in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Proximal events in Wnt signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Novel systemic therapies for small cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2010.196

Wild-type human p53 activates the human epidermal growth factor receptor promoter

31 March 2020

1 reference

12 December 2020

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

1 reference

12 December 2020

Phase I trial of exisulind (sulindac sulfone, FGN-1) as a chemopreventive agent in patients with familial adenomatous polyposis

1 reference

12 December 2020

Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors

1 reference

12 December 2020

Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects

1 reference

12 December 2020

Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors.

1 reference

12 December 2020

Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship

1 reference

12 December 2020

Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways

1 reference

12 December 2020

10.1038/NRCLINONC.2010.196

Identifiers

DOI

1 reference

23 August 2017

1 reference