(Q36382763)

13 August 2017

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title

Strength of signal: a fundamental mechanism for cell fate specification (English)

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13 August 2017

Sandra M Hayes

1

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13 August 2017

Paul E Love

series ordinal

2

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13 August 2017

publication date

1 February 2006

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13 August 2017

published in

Immunological Reviews

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13 August 2017

volume

209

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13 August 2017

page(s)

170-175

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Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-gamma production

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Signal strength in thymic selection and lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

T-cell development and the CD4-CD8 lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

B cell receptor signal strength determines B cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Positive selection and lineage commitment during peripheral B-lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Events that regulate differentiation of alpha beta TCR+ and gamma delta TCR+ T cells from a common precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

The role of the T-cell receptor (TCR) in alpha beta/gamma delta lineage commitment: clues from intracellular TCR staining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

The alpha beta versus gamma delta T-cell lineage choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Intrathymic delta selection events in gammadelta cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

T cell receptor gamma gene regulatory sequences prevent the function of a novel TCRgamma/pTalpha pre-T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Structure and function of the pre-T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Regulatory principles of developmental signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Signal processing underlying extrinsic control of stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Morphogens and pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Morphogen gradient interpretation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Thrombotic cocktail in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Different initiation of pre-TCR and gammadeltaTCR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Constitutive endocytosis and degradation of the pre-T cell receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

The role of morphogens in T-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00356.X

10.1111/J.0105-2896.2006.00356.X

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference