(Q36384459)

13 August 2017

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title

Therapeutic short hairpin RNA expression in the liver: viral targets and vectors (English)

1 reference

13 August 2017

Grimm D

1

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PubMed ID

16453009

13 August 2017

Kay MA

series ordinal

2

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13 August 2017

1 March 2006

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13 August 2017

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13 August 2017

13

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13 August 2017

563-575

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13 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302727

13 August 2017

0 references

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Challenges and successes in developing new therapies for hepatitis C.

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Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

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Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs

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Caspase 8 small interfering RNA prevents acute liver failure in mice

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Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus

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21 January 2018

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siRNA-mediated inhibition of HBV replication and expression

21 January 2018

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Effect of vector-expressed siRNA on HBV replication in hepatoblastoma cells

21 January 2018

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Inhibition of human La protein by RNA interference downregulates hepatitis B virus mRNA in 2.2.15 cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

21 January 2018

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21 January 2018

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21 January 2018

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Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model

21 January 2018

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Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

21 January 2018

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21 January 2018

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Small interfering RNA effectively inhibits protein expression and negative strand RNA synthesis from a full-length hepatitis C virus clone

21 January 2018

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21 January 2018

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21 January 2018

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A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia

21 January 2018

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21 January 2018

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Progress and problems with the use of viral vectors for gene therapy

21 January 2018

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21 January 2018

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Adeno-associated virus vectors for short hairpin RNA expression

21 January 2018

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A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo

21 January 2018

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Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Gutted adenovirus: a rising star on the horizon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Production methods for gene transfer vectors based on adeno-associated virus serotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Determinants of interferon-stimulated gene induction by RNAi vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Cre-lox-regulated conditional RNA interference from transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

A new vector, based on the PolII promoter of the U1 snRNA gene, for the expression of siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Noise amidst the silence: off-target effects of siRNAs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Looking into the safety of AAV vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

Hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

7 January 2021

Primary hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

7 January 2021

High-level hepatitis B virus replication in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

7 January 2021

Therapies for hepatitis B: where to from here?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302727

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302727

1 reference

13 August 2017

1 reference

PubMed ID

16453009