(Q36385974)

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CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

pancreatic cancer

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based on heuristic

inferred from title

author name string

Ajay P Singh

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Sumit Arora

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Arun Bhardwaj

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Sanjeev K Srivastava

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Madhavi P Kadakia

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Bin Wang

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

William E Grizzle

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Laurie B Owen

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Seema Singh

9

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Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

20 September 2012

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

13 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

46

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

39115-39124

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Accessories to the crime: functions of cells recruited to the tumor microenvironment

1 reference

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30 September 2017

The diverse and complex roles of NF-κB subunits in cancer

1 reference

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30 September 2017

Cancer statistics, 2012

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Inflammation meets cancer, with NF-κB as the matchmaker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

The Hedgehog's tale: developing strategies for targeting cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Tumor microenvironment and progression of pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Hallmarks of Cancer: The Next Generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Hedgehog signaling and therapeutics in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Stromal biology and therapy in pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL12 (SDF-1)/CXCR4 pathway in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Modeling pancreatic cancer in vivo: from xenograft and carcinogen-induced systems to genetically engineered mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCR7 functions as a scavenger for CXCL12 and CXCL11

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL12/CXCR4 promotes motility and proliferation of glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Sonic hedgehog promotes desmoplasia in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo

1 reference

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30 September 2017

A paracrine requirement for hedgehog signalling in cancer

1 reference

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30 September 2017

The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia.

1 reference

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30 September 2017

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

1 reference

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30 September 2017

Control of chemokine-guided cell migration by ligand sequestration

1 reference

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30 September 2017

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

1 reference

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30 September 2017

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

1 reference

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30 September 2017

Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

1 reference

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30 September 2017

The hedgehog signaling pathway in cancer

1 reference

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30 September 2017

p63 overexpression induces the expression of Sonic Hedgehog.

1 reference

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30 September 2017

Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4.

1 reference

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30 September 2017

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Pancreatic cancer biology and genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1 reference

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30 September 2017

Activating Smoothened mutations in sporadic basal-cell carcinoma

1 reference

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30 September 2017

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

30 September 2017

Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

28 June 2018

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

28 June 2018

Sporadic medulloblastomas contain PTCH mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

28 June 2018

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493952

21 September 2018

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

1 reference

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21 September 2018

Identifiers

10.1074/JBC.M112.409581

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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