(Q36392833)

13 August 2017

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title

Integrated signalling pathways for mast-cell activation (English)

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13 August 2017

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1

Alasdair M Gilfillan

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13 August 2017

Christine Tkaczyk

2

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13 August 2017

publication date

1 March 2006

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Nature Reviews Immunology

13 August 2017

published in

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13 August 2017

volume

6

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13 August 2017

issue

3

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13 August 2017

page(s)

218-230

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13 August 2017

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Heterogeneity of mast cells and phenotypic change between subpopulations

31 March 2020

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Mast cells in the development of adaptive immune responses

31 March 2020

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The mastocyte: the "other" inflammatory cell in immunopathogenesis

31 March 2020

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Mast-cell responses to pathogens.

31 March 2020

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The receptor with high affinity for IgE.

31 March 2020

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A role for lipid rafts in B cell antigen receptor signaling and antigen targeting

31 March 2020

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Membrane compartmentation is required for efficient T cell activation.

31 March 2020

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Structural aspects of the association of FcepsilonRI with detergent-resistant membranes

31 March 2020

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Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

31 March 2020

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Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

31 March 2020

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Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation

31 March 2020

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Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation

31 March 2020

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Functions of lipid rafts in biological membranes

31 March 2020

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A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation

31 March 2020

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Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

31 March 2020

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Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase

31 March 2020

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Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation

31 March 2020

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Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

31 March 2020

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Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

31 March 2020

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The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production

31 March 2020

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Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics

31 March 2020

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Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signaling.

31 March 2020

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LAT is essential for Fc(epsilon)RI-mediated mast cell activation

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development

31 March 2020

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Molecular adapters in Fc(epsilon)RI signaling and the allergic response

31 March 2020

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ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells

31 March 2020

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

31 March 2020

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Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development

31 March 2020

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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

31 March 2020

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LAB: a new membrane-associated adaptor molecule in B cell activation

31 March 2020

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Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.

31 March 2020

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NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation

31 March 2020

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Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL

31 March 2020

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NTAL/LAB and LAT: a balancing act in mast-cell activation and function

31 March 2020

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Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes

31 March 2020

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Early signaling pathways activated by c-Kit in hematopoietic cells

31 March 2020

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A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

31 March 2020

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SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

31 March 2020

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FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

31 March 2020

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The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation

31 March 2020

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Signal transduction by Fc receptors: the Fc epsilon RI case

31 March 2020

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Depletion of intracellular calcium stores activates a calcium current in mast cells

31 March 2020

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Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?

31 March 2020

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Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells

31 March 2020

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The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

31 March 2020

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Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

31 March 2020

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

31 March 2020

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

31 March 2020

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Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2

31 March 2020

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

31 March 2020

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Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

31 March 2020

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Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway

31 March 2020

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Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells

31 March 2020

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Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity

31 March 2020

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Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun

31 March 2020

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Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway

31 March 2020

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FcR gamma chain deletion results in pleiotrophic effector cell defects

31 March 2020

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Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

31 March 2020

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Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

31 March 2020

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Essential role for Gab2 in the allergic response

31 March 2020

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Synthesis and function of 3-phosphorylated inositol lipids

31 March 2020

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Roles of adaptor molecules in mast cell activation

31 March 2020

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Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

31 March 2020

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Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

31 March 2020

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Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production

31 March 2020

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BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.

31 March 2020

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Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase

31 March 2020

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The role of sphingosine kinase in the signaling initiated at the high-affinity receptor for IgE (FcepsilonRI) in mast cells

31 March 2020

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Sphingolipids and the balancing of immune cell function: lessons from the mast cell

31 March 2020

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Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

31 March 2020

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Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells

31 March 2020

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Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

31 March 2020

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

31 March 2020

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Akt-dependent cytokine production in mast cells

31 March 2020

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Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells

31 March 2020

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Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

31 March 2020

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c-kit ligand: a unique potentiator of mediator release by human lung mast cells

31 March 2020

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Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells

31 March 2020

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Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions

31 March 2020

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T cell costimulation by chemokine receptors

31 March 2020

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The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering

31 March 2020

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Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase.

31 March 2020

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Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a.

31 March 2020

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The role of PI3K in immune cells

31 March 2020

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The case for a role for adenosine in asthma: almost convincing?

31 March 2020

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Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation

31 March 2020

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Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biologic

31 March 2020

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A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI.

31 March 2020

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Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation

31 March 2020

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Expression and function of Fc gamma R in mouse mast cells

31 March 2020

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CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13.

31 March 2020

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Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release

31 March 2020

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IL-4 selectively enhances FcγRIII expression and signaling on mouse mast cells

31 March 2020

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IL-4 enhances proliferation and mediator release in mature human mast cells

31 March 2020

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IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production

31 March 2020

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IL-10 inhibits Fc epsilon RI expression in mouse mast cells

31 March 2020

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Inhibition of IgE-induced activation of human mast cells by IL-10.

31 March 2020

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TGF-beta1 inhibits the release of histamine and tumor necrosis factor-alpha from mast cells through an autocrine pathway

31 March 2020

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TGF-beta 1 inhibits mast cell Fc epsilon RI expression

31 March 2020

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Defective degranulation and calcium mobilization of bone-marrow derived mast cells from Xid and Btk-deficient mice

31 March 2020

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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1782

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release_eznadccumjav7fepvv72u3g5pu

13 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/eznadccumjav7fepvv72u3g5pu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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