(Q36399692)

14 August 2017

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene (English)

1 reference

hemophagocytic lymphohistiocytosis

14 August 2017

1 reference

1 reference

Phillip K Darcy

7

0 references

Joseph A. Trapani

Joseph A Trapani

10

0 references

Mark J. Smyth

Mark J Smyth

9

0 references

Stephen M Jane

Stephen M Jane

8

0 references

Jacob T Jackson

6

Jacob T Jackson

1 reference

14 August 2017

5

Erika Cretney

1 reference

14 August 2017

Ilia Voskoboinik

1

1 reference

14 August 2017

Marie-Claude Thia

2

1 reference

14 August 2017

Annette De Bono

3

1 reference

14 August 2017

Kylie Browne

4

1 reference

14 August 2017

language of work or name

English

0 references

publication date

14 September 2004

1 reference

Journal of Experimental Medicine

14 August 2017

1 reference

14 August 2017

200

1 reference

14 August 2017

6

1 reference

14 August 2017

811-816

1 reference

Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis.

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Functional significance of the perforin/granzyme cell death pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Dual mechanisms of apoptosis induction by cytotoxic lymphocytes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Characterization of recombinant mouse perforin expressed in insect cells using the baculovirus system

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211966

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20040776

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20040776

Perforin is a major contributor to NK cell control of tumor metastasis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15365097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15365097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20040776

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

15365097

1 reference