(Q36401327)

14 August 2017

Visualization of CD4/CD8 T cell commitment (English)

1 reference

14 August 2017

1 reference

Chan S

1

1 reference

14 August 2017

Correia-Neves M

2

1 reference

14 August 2017

Dierich A

3

1 reference

14 August 2017

Benoist C

4

1 reference

14 August 2017

Mathis D

5

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 December 1998

1 reference

Journal of Experimental Medicine

14 August 2017

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14 August 2017

188

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14 August 2017

12

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14 August 2017

2321-2333

1 reference

Two distinct pathways of positive selection for thymocytes

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

T cell receptor antagonist peptides induce positive selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

A challenge to the instructive model of positive selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

A transcriptional silencer controls the developmental expression of the CD4 gene.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Selective events in T cell development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Evidence for a single-niche model of positive selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Role of coreceptors in positive selection and lineage commitment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Stochastic component to development of class I major histocompatibility complex-specific T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Molecular and cellular events of T cell development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Mice lacking MHC class II molecules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Development of the CD4 and CD8 lineage of T cells: instruction versus selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Activation events during thymic selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

The influence of the MAPK pathway on T cell lineage commitment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Positive selection induces CD4 promoter and enhancer function.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Mouse CD1-specific NK1 T cells: development, specificity, and function

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Development of mature CD8+ thymocytes: selection rather than instruction?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212422

Another view of the selective model of thymocyte selection.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

The selection of the α,β heterodimeric T-cell receptor for antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Differentiation of CD4(high)CD8(low) coreceptor-skewed thymocytes into mature CD8 single-positive cells independent of MHC class I recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Lymphocyte populations and immune responses in CD5-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Thymocytes control the CD4 gene differently from mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.188.12.2321

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9858518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.188.12.2321

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

9858518

1 reference