(Q36401746)

14 August 2017

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title

Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials (English)

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14 August 2017

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Maria Thomas

1

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14 August 2017

Johann Greil

series ordinal

2

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14 August 2017

Olaf Heidenreich

series ordinal

3

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14 August 2017

1 March 2006

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Acta Pharmacologica Sinica

14 August 2017

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14 August 2017

27

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14 August 2017

3

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14 August 2017

273-281

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https://scigraph.springernature.com/pub.10.1111/j.1745-7254.2006.00282.x

14 August 2017

0 references

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Defining and assaying RNAi in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Targeted mRNA degradation by double-stranded RNA in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNA interference and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNA interference as a potential tool in the treatment of leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Epigenetic treatment of hematopoietic malignancies: in vivo targets of demethylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

The functions of animal microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNA interference in human cells is restricted to the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Lentiviral-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Roots of clinical resistance to STI-571 cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Efficient silencing of bcr/abl oncogene by single- and double-stranded siRNAs targeted against b2a2 transcripts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Specific killing of Ph+ chronic myeloid leukemia cells by a lentiviral vector-delivered anti-bcr/abl small hairpin RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Stable RNA interference (RNAi) as an option for anti-bcr-abl therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Inhibition of bcr-abl and/or c-abl gene expression by small interfering, double-stranded RNAs: cross-talk with cell proliferation factors and other oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

MLL-rearranged leukemias: insights from gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

MicroRNAs modulate hematopoietic lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RAS is regulated by the let-7 microRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00282.X

10.1111/J.1745-7254.2006.00282.X

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

14 August 2017

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1 reference