(Q36402212)

14 August 2017

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title

Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics (English)

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14 August 2017

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3

John D Potter

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14 August 2017

Cornelia M Ulrich

1

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14 August 2017

Jeannette Bigler

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 February 2006

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14 August 2017

Nature Reviews Cancer

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14 August 2017

6

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14 August 2017

130-140

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14 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrc1801

14 August 2017

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cites work

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Radical causes of cancer.

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Chemical basis of inflammation-induced carcinogenesis

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Inflammation and cancer

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COX-2: a molecular target for colorectal cancer prevention

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Aspirin use and reduced risk of fatal colon cancer

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Aspirin and colorectal cancer

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Nonsteroidal antiinflammatory drugs and colorectal cancer.

21 January 2018

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Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer

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Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme

21 January 2018

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A randomized trial of aspirin to prevent colorectal adenomas

21 January 2018

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A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

21 January 2018

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Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis

21 January 2018

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Prostate cancer and use of nonsteroidal anti-inflammatory drugs: systematic review and meta-analysis

21 January 2018

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Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis

21 January 2018

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Aspirin use and lung cancer in men

21 January 2018

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Prostate carcinogenesis and inflammation: emerging insights.

21 January 2018

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Epidemiology of non-steroidal anti-inflammatory drugs and cancer

21 January 2018

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Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk

21 January 2018

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

21 January 2018

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Cyclooxygenases: structural, cellular, and molecular biology

21 January 2018

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

21 January 2018

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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

21 January 2018

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Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues

21 January 2018

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Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat.

21 January 2018

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Prostaglandin synthase 2.

21 January 2018

1 reference

Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor

21 January 2018

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Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

21 January 2018

1 reference

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

21 January 2018

1 reference

Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice

21 January 2018

1 reference

Cellular regulation of prostaglandin H synthase catalysis.

21 January 2018

1 reference

Prostaglandins and cancer: an update

21 January 2018

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Prostaglandins from tumours of human large bowel

21 January 2018

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Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2

21 January 2018

1 reference

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

21 January 2018

1 reference

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect

21 January 2018

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Localization of cyclooxygenase-2 in human sporadic colorectal adenomas

21 January 2018

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15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer

21 January 2018

1 reference

15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers

21 January 2018

1 reference

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 January 2018

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Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects

21 January 2018

1 reference

15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells

21 January 2018

1 reference

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.

21 January 2018

1 reference

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells

21 January 2018

1 reference

Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac

21 January 2018

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The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells

21 January 2018

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PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

21 January 2018

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Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

21 January 2018

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Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

21 January 2018

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

21 January 2018

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APC mutations occur early during colorectal tumorigenesis

21 January 2018

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Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis.

21 January 2018

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Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment. Advantages of a low-dose nonsteroidal anti-inflammatory drug regimen in reversing ad

21 January 2018

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The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

21 January 2018

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Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

21 January 2018

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Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine

21 January 2018

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Renal toxicity of the nonsteroidal anti-inflammatory drugs

21 January 2018

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Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study

21 January 2018

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Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs.

21 January 2018

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Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

21 January 2018

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Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery

21 January 2018

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Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

21 January 2018

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Coxibs and cardiovascular disease

21 January 2018

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COX inhibitors and thromboregulation

21 January 2018

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Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence

21 January 2018

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Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

21 January 2018

1 reference

New paradigms for cancer prevention.

21 January 2018

1 reference

What happened to the coxibs on the way to the cardiologist?

21 January 2018

1 reference

Pharmacokinetic variability of anticancer agents

21 January 2018

1 reference

Cancer pharmacogenetics: polymorphisms, pathways and beyond

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs and aspirin for the prevention of colorectal adenomas and cancer: a systematic review

21 January 2018

1 reference

Use of NSAIDs for the Chemoprevention of Colorectal Cancer

21 January 2018

1 reference

COX-2 inhibition and colorectal cancer

21 January 2018

1 reference

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

21 January 2018

1 reference

Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib

21 January 2018

1 reference

Clinical pharmacokinetics of the salicylates

21 January 2018

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Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics.

21 January 2018

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Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

21 January 2018

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Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2.

21 January 2018

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The metabolism of aspirin in man: a population study

21 January 2018

1 reference

Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.

21 January 2018

1 reference

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

21 January 2018

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Involvement of CYP2C9 and UGT2B7 in the metabolism of zaltoprofen, a nonsteroidal anti-inflammatory drug, and its lack of clinically significant CYP inhibition potential

21 January 2018

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Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism

21 January 2018

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Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes.

21 January 2018

1 reference

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

21 January 2018

1 reference

Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation

21 January 2018

1 reference

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

21 January 2018

1 reference

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid

21 January 2018

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Dose-effect relationships of nonsteroidal anti-inflammatory drugs: a literature review

21 January 2018

1 reference

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics

21 January 2018

1 reference

Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites

21 January 2018

1 reference

Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma

21 January 2018

1 reference

Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations

21 January 2018

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Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

21 January 2018

1 reference

Genetic variation in cyclooxygenase 1: effects on response to aspirin

21 January 2018

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Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure

21 January 2018

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A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke

21 January 2018

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Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study

21 January 2018

1 reference

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer

21 January 2018

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PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs

21 January 2018

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Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.

21 January 2018

1 reference

Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps

21 January 2018

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COX-2-derived prostacyclin confers atheroprotection on female mice

21 January 2018

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Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacylcin synthase gene (CYP8A1).

21 January 2018

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Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1).

21 January 2018

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Novel polymorphic CA/TG repeat identified in the human prostacyclin synthase gene.

21 January 2018

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Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial

21 January 2018

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Dual Association of beta-carotene with risk of tobacco-related cancers in a cohort of French women

21 January 2018

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Aspirin and the Risk of Colorectal Cancer in Women

21 January 2018

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Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer

21 January 2018

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Treatment of Chemically-Induced Intestinal Cancers with Indomethacin

21 January 2018

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Aspirin use and p53 expression in colorectal cancer

31 March 2020

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Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer

31 March 2020

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Aspirin use, cancer, and polyps of the large bowel

31 March 2020

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Aspirin use and the risk for colorectal cancer and adenoma in male health professionals

31 March 2020

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Aspirin use and lung, colon, and breast cancer incidence in a prospective study

31 March 2020

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Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group

31 March 2020

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Cyclooxygenase-2 inhibitors in tumorigenesis (part I)

31 March 2020

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Hydroperoxide dependence and cooperative cyclooxygenase kinetics in prostaglandin H synthase-1 and -2

31 March 2020

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31 March 2020

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The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

31 March 2020

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Metabolism and kinetics of oxaprozin in normal subjects

31 March 2020

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Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS.

31 March 2020

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Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4

31 March 2020

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In vitro oxidation of oxicam NSAIDS by a human liver cytochrome P450

31 March 2020

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Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen

31 March 2020

1 reference

Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7

31 March 2020

1 reference

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

31 March 2020

1 reference

The need for a systematic approach to complex pathways in molecular epidemiology

31 March 2020

1 reference

Organization of the human prostacyclin synthase gene and association analysis of a novel CA repeat in essential hypertension

31 March 2020

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Association of 5' upstream promoter region of prostacyclin synthase gene variant with cerebral infarction

31 March 2020

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Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1801

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Dimensions Publication ID

14 August 2017

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