(Q36402237)

14 August 2017

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title

Journey through the thymus: stromal guides for T-cell development and selection (English)

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14 August 2017

Yousuke Takahama

1

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14 August 2017

language of work or name

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1 February 2006

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Nature Reviews Immunology

14 August 2017

published in

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14 August 2017

volume

6

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14 August 2017

issue

2

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14 August 2017

page(s)

127-135

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IMMUNOLOGICAL FUNCTION OF THE THYMUS

14 August 2017

cites work

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In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

21 January 2018

1 reference

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

21 January 2018

1 reference

Intrathymic and Extrathymic T Cell Maturation

21 January 2018

1 reference

Location of T cell and major histocompatibility complex antigens in the human thymus

21 January 2018

1 reference

Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

21 January 2018

1 reference

Controlling the thymic microenvironment.

21 January 2018

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Kinetics of mature T-cell development in the thymus

21 January 2018

1 reference

Crosstalk in the mouse thymus

21 January 2018

1 reference

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.

21 January 2018

1 reference

Tissue interaction in the development of thymus lymphocytes

21 January 2018

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Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment

21 January 2018

1 reference

The role of CCL21 in recruitment of T-precursor cells to fetal thymi

21 January 2018

1 reference

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ + gut intraepithelial lymphocytes

21 January 2018

1 reference

A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo

21 January 2018

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Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

21 January 2018

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The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice

21 January 2018

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Tracing of cells of the avian thymus through embryonic life in interspecific chimeras

21 January 2018

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Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

21 January 2018

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Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras

21 January 2018

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Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves

21 January 2018

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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

21 January 2018

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V delta repertoire during thymic ontogeny suggests three novel waves of gamma delta TCR expression.

21 January 2018

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A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor

21 January 2018

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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T-cell development made simple

21 January 2018

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

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Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

21 January 2018

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Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

21 January 2018

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Thymic T cell development and progenitor localization depend on CCR7.

21 January 2018

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Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development.

21 January 2018

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Structure and function of the pre-T cell receptor

21 January 2018

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

21 January 2018

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

21 January 2018

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Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta

21 January 2018

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Positive selection of thymocytes

21 January 2018

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Directed migration of positively selected thymocytes visualized in real time

21 January 2018

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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

21 January 2018

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CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

21 January 2018

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CCR7 directs the migration of thymocytes into the thymic medulla

21 January 2018

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The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

21 January 2018

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Expression of relB is required for the development of thymic medulla and dendritic cells

21 January 2018

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

21 January 2018

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NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

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Dependence of self-tolerance on TRAF6-directed development of thymic stroma

21 January 2018

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Activation events during thymic selection

21 January 2018

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Self-representation in the thymus: an extended view

21 January 2018

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Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

21 January 2018

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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Aire regulates negative selection of organ-specific T cells

21 January 2018

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

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The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

21 January 2018

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

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Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.

21 January 2018

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Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection

21 January 2018

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A pertussis toxin-sensitive process controls thymocyte emigration

21 January 2018

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

21 January 2018

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Enzymatic measurement of sphingosine 1-phosphate

21 January 2018

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Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

21 January 2018

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Thymocyte emigration is mediated by active movement away from stroma-derived factors

21 January 2018

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Thymic microvascular system.

21 January 2018

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Compartmentalized Eph receptor and ephrin expression in the thymus

21 January 2018

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Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines?

21 January 2018

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Thymic generation and regeneration

21 January 2018

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Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens

21 January 2018

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Efficient generation of human T cells from a tissue-engineered thymic organoid

21 January 2018

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From stem cell to T cell: one route or many?

21 January 2018

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T/B lineage choice occurs prior to intrathymic Notch signaling.

21 January 2018

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Notch signaling controls the generation and differentiation of early T lineage progenitors

21 January 2018

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A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision

21 January 2018

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Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1.

21 January 2018

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Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling

21 January 2018

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Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs

21 January 2018

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Developmental regulation of T-cell receptor gene expression

21 January 2018

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Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

21 January 2018

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Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice

21 January 2018

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Selecting and maintaining a diverse T-cell repertoire

31 March 2020

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Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment

31 March 2020

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Chemokines define distinct microenvironments in the developing thymus

31 March 2020

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Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

31 March 2020

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Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus

31 March 2020

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Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

31 March 2020

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In Vivo Treatment of Class II MHC-Deficient Mice with Anti-TCR Antibody Restores the Generation of Circulating CD4 T Cells and Optimal Architecture of Thymic Medulla

31 March 2020

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Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

31 March 2020

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A scanning electron-microscopic study of the rat thymus with special reference to cell types and migration of lymphocytes into the general circulation

31 March 2020

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Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

31 March 2020

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Involvement of E-cadherin in thymus organogenesis and thymocyte maturation

31 March 2020

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Enhancement of stromal cell-derived factor-1alpha-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice

31 March 2020

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Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

31 March 2020

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Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25

31 March 2020

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Stromal-derived factor 1 expression in the human thymus

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1781

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14 August 2017

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