(Q36412120)

14 August 2017

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title

Factor VIII structure and function. (English)

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14 August 2017

Philip J Fay

1

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14 August 2017

language of work or name

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1 February 2006

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International Journal of Hematology

14 August 2017

published in

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14 August 2017

volume

83

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14 August 2017

issue

2

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14 August 2017

page(s)

103-108

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Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase

14 August 2017

cites work

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12 December 2020

Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII.

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12 December 2020

Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site

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12 December 2020

Electron crystallography of human blood coagulation factor VIII bound to phospholipid monolayers

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12 December 2020

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

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12 December 2020

A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin.

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12 December 2020

Role of activation of the coagulation factor VIII in interaction with vWf, phospholipid, and functioning within the factor Xase complex

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12 December 2020

Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa

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12 December 2020

Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit

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12 December 2020

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

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12 December 2020

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

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12 December 2020

Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking.

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12 December 2020

Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor

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12 December 2020

Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity

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12 December 2020

Copper-atom identification in the active and inactive forms of plasma-derived FVIII and recombinant FVIII-delta II

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12 December 2020

Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity

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12 December 2020

The regulation of clotting factors

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12 December 2020

Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding

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12 December 2020

Mutating factor VIII: lessons from structure to function

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12 December 2020

Activation of factor VIII and mechanisms of cofactor action

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12 December 2020

Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa

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12 December 2020

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy

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12 December 2020

Structure of human factor VIII

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12 December 2020

Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa

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12 December 2020

Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation.

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12 December 2020

The life cycle of coagulation factor VIII in view of its structure and function

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12 December 2020

Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa

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12 December 2020

A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase

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12 December 2020

Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689

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12 December 2020

The A2 subunit of factor VIIIa modulates the active site of factor IXa.

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12 December 2020

Molecular cloning of a cDNA encoding human antihaemophilic factor

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12 December 2020

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII

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12 December 2020

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

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12 December 2020

Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa

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12 December 2020

Structure of the C2 domain of human factor VIII at 1.5 A resolution

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12 December 2020

The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function

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12 December 2020

Mn2+ binding to factor VIII subunits and its effect on cofactor activity

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12 December 2020

Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII

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12 December 2020

3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography

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12 December 2020

Mechanism of factor Va inactivation by plasmin. Loss of A2 and A3 domains from a Ca2+-dependent complex of fragments bound to phospholipid

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12 December 2020

Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity

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12 December 2020

The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4

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12 December 2020

Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.

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12 December 2020

Familial discrepancy between the one-stage and two-stage factor VIII methods in a subgroup of patients with haemophilia A.

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12 December 2020

Localization of a factor X interactive site in the A1 subunit of factor VIIIa

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12 December 2020

Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase

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12 December 2020

Structural requirements for the activation of human factor VIII by thrombin

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12 December 2020

Expression of active human factor VIII from recombinant DNA clones

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12 December 2020

A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation

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12 December 2020

Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex

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12 December 2020

Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis

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12 December 2020

Expression of factor VIII by murine liver sinusoidal endothelial cells

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12 December 2020

Inhibition of human factor VIIIa by anti-A2 subunit antibodies

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12 December 2020

Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336.

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12 December 2020

Anticoagulant effects of a synthetic peptide containing residues Thr-2253-Gln-2270 within factor VIII C2 domain that selectively inhibits factor Xa-catalysed factor VIII activation

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12 December 2020

Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain

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12 December 2020

Mutations in a subgroup of patients with mild haemophilia A and a familial discrepancy between the one-stage and two-stage factor VIII:C methods

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12 December 2020

Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain

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12 December 2020

Identifiers

DOI

10.1532/IJH97.05113

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Dimensions Publication ID

14 August 2017

1036193024

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