(Q36420699)

14 August 2017

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title

Human monogenic disorders - a source of novel drug targets (English)

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14 August 2017

2

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14 August 2017

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Guy A Rouleau

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Ryan R Brinkman

object named as

Ryan R Brinkman

series ordinal

1

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author name string

Andrew C Orr

series ordinal

4

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14 August 2017

Mark E Samuels

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5

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14 August 2017

publication date

1 April 2006

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14 August 2017

published in

Nature Reviews Genetics

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14 August 2017

volume

7

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14 August 2017

issue

4

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14 August 2017

page(s)

249-260

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FDA publishes analysis of the pipeline problem

14 August 2017

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A candidate prostate cancer susceptibility gene at chromosome 17p

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

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The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

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Increased ABCA1 activity protects against atherosclerosis.

31 March 2020

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Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

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Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

31 March 2020

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SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels

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Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

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Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity

31 March 2020

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31 March 2020

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31 March 2020

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Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy

31 March 2020

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Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy

31 March 2020

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Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes

31 March 2020

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A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling.

31 March 2020

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Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

31 March 2020

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Do essential genes evolve slowly?

31 March 2020

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Glycoprotein IIb/IIIa integrin blockade

31 March 2020

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New drug targets for genomic cancer therapy: successes, limitations, opportunities and future challenges.

31 March 2020

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Modulation of protein-protein interactions with small organic molecules

31 March 2020

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

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Emerging classes of protein-protein interaction inhibitors and new tools for their development

31 March 2020

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Inhibiting protein-protein interactions using designed molecules

31 March 2020

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Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene

31 March 2020

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Use of population isolates for mapping complex traits

31 March 2020

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Accurate multiplex polony sequencing of an evolved bacterial genome

31 March 2020

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Pharmacogenetics goes genomic

31 March 2020

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31 March 2020

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The promise of genomics to identify novel therapeutic targets

31 March 2020

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FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1828

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14 August 2017

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