(Q36429400)

14 August 2017

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title

Potential applications of RNA interference technology in the treatment of cancer (English)

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14 August 2017

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Hermann Lage

1

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PubMed ID

16555980

14 August 2017

language of work or name

English

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publication date

1 February 2005

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14 August 2017

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14 August 2017

1

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14 August 2017

1

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14 August 2017

103-113

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

A species of small antisense RNA in posttranscriptional gene silencing in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Emerging clinical applications of RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Gene silencing in mammals by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

ATP requirements and small interfering RNA structure in the RNA interference pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

A simple and cost-effective method for producing small interfering RNAs with high efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Short interfering RNA confers intracellular antiviral immunity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Cloned zebrafish by nuclear transfer from long-term-cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Effective expression of small interfering RNA in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inducible shRNA expression for application in a prostate cancer mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Establishment of conditional vectors for hairpin siRNA knockdowns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inducible, reversible, and stable RNA interference in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Efficient lentiviral vectors for short hairpin RNA delivery into human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Gene silencing by adenovirus-delivered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Adenovirus vector-mediated doxycycline-inducible RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Unlocking the potential of the human genome with RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

PKR, apoptosis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Gene structure and function of the 2'-5'-oligoadenylate synthetase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Expression of platelet glycoprotein (GP) V in heterologous cells and evidence for its association with GP Ib alpha in forming a GP Ib-IX-V complex on the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

STI571 as a targeted therapy for CML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of bcr-abl and/or c-abl gene expression by small interfering, double-stranded RNAs: cross-talk with cell proliferation factors and other oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

ABC-transporters: implications on drug resistance from microorganisms to human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

The reversal of multidrug resistance: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Multidrug resistance reversal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Stable suppression of MDR1 gene expression and function by RNAi in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Reversal of P-glycoprotein-mediated multidrug resistance with small interference RNA (siRNA) in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Strategies for inhibition of MDR1 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Small interfering RNA targeting bcl-2 sensitizes malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Low p21Waf1/Cip1 protein level sensitizes testicular germ cell tumor cells to Fas-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA against Her-2/neu gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

B-RAF is a therapeutic target in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by e6 siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Suppression of Epstein-Barr virus-encoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of nasopharyngeal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Efficient RNA interference (RNAi) in Mamallian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

Specific killing of Ph+ chronic myeloid leukemia cells by a lentiviral vector-delivered anti-bcr/abl small hairpin RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.1.103

21 January 2018

Identifiers

DOI

10.1517/14796694.1.1.103

1 reference

14 August 2017

1 reference

PubMed ID

16555980