(Q36439713)

14 August 2017

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title

Multidrug resistance-associated proteins 3, 4, and 5. (English)

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14 August 2017

multiple drug resistance

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Piet Borst

1

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PubMed ID

16586096

14 August 2017

Cornelia de Wolf

series ordinal

2

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PubMed ID

16586096

14 August 2017

Koen van de Wetering

series ordinal

3

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14 August 2017

4 April 2006

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14 August 2017

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14 August 2017

453

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14 August 2017

5

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14 August 2017

661-673

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https://scigraph.springernature.com/pub.10.1007/s00424-006-0054-9

14 August 2017

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cites work

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter

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12 December 2020

Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione

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12 December 2020

Hepatic secretion of conjugated drugs and endogenous substances

1 reference

12 December 2020

Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis

1 reference

12 December 2020

Pharmacogenetics of hepatocellular transporters

1 reference

12 December 2020

pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells

1 reference

12 December 2020

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

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12 December 2020

Characterization of inducible nature of MRP3 in rat liver

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12 December 2020

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

1 reference

12 December 2020

Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma

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12 December 2020

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells

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12 December 2020

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

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12 December 2020

Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic Anions

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12 December 2020

Induction of ABCC3 (MRP3) by pregnane X receptor activators

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12 December 2020

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

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12 December 2020

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

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12 December 2020

Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.

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12 December 2020

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database

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12 December 2020

Transport of amphipathic anions by human multidrug resistance protein 3

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12 December 2020

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.

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12 December 2020

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

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12 December 2020

Immunolocalization of multidrug resistance protein 5 in the human genitourinary system

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12 December 2020

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

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12 December 2020

Analysis of the in vivo functions of Mrp3.

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12 December 2020

Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia

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12 December 2020

Influence of omeprazole on multidrug resistance protein 3 expression in human liver

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12 December 2020

Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene

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12 December 2020

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12 December 2020

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance

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12 December 2020

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

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12 December 2020

Tissue distribution and induction of human multidrug resistant protein 3

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12 December 2020

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

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12 December 2020

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells

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12 December 2020

The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.

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12 December 2020

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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12 December 2020

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

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12 December 2020

Efflux transport systems for organic anions and cations at the blood-CSF barrier

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12 December 2020

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

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12 December 2020

Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine.

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12 December 2020

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

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12 December 2020

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

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12 December 2020

The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype

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12 December 2020

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor

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12 December 2020

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

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12 December 2020

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

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12 December 2020

cGMP (guanosine 3',5'-cyclic monophosphate) transport across human erythrocyte membranes

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12 December 2020

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

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12 December 2020

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

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12 December 2020

Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing

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12 December 2020

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines

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12 December 2020

Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer.

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12 December 2020

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

1 reference

12 December 2020

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.

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12 December 2020

The (patho)physiological functions of the MRP family

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12 December 2020

The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy.

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12 December 2020

Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

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12 December 2020

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver.

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12 December 2020

MRP3, an organic anion transporter able to transport anti-cancer drugs

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12 December 2020

The role of multidrug transporters in drug availability, metabolism and toxicity

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12 December 2020

Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

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12 December 2020

Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats.

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12 December 2020

Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages

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12 December 2020

Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tract

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12 December 2020

Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart

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12 December 2020

The MRP family of drug efflux pumps

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12 December 2020

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

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12 December 2020

Pharmacological characterization of the ATP-dependent low K(m) guanosine 3',5'-cyclic monophosphate (cGMP) transporter in human erythrocytes

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12 December 2020

Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man.

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12 December 2020

Export of guanosine 3',5'-cyclic monophosphate (cGMP) from human erythrocytes characterized by inside-out membrane vesicles

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12 December 2020

Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

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12 December 2020

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

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12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

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12 December 2020

Human red blood cells: rheological aspects, uptake, and release of cytotoxic drugs

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12 December 2020

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

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12 December 2020

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines

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12 December 2020

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

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12 December 2020

Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes

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12 December 2020

The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design

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12 December 2020

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

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12 December 2020

Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation

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12 December 2020

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

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12 December 2020

Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.

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12 December 2020

Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility

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12 December 2020

Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma

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12 December 2020

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

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12 December 2020

Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

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12 December 2020

Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport

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12 December 2020

Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles

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12 December 2020

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

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12 December 2020

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

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12 December 2020

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)

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12 December 2020

Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter

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12 December 2020

Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites

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12 December 2020

ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)

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12 December 2020

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

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12 December 2020

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

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12 December 2020

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

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12 December 2020

Cyclic GMP transporters

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12 December 2020

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

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12 December 2020

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

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12 December 2020

Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3.

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12 December 2020

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

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12 December 2020

On the putative co-transport of drugs by multidrug resistance proteins

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12 December 2020

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

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12 December 2020

Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins

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12 December 2020

Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride

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12 December 2020

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

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12 December 2020

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

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12 December 2020

Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5.

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12 December 2020

cGMP and glutathione-conjugate transport in human erythrocytes

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12 December 2020

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

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12 December 2020

10.1007/S00424-006-0054-9

Identifiers

DOI

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14 August 2017

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PubMed ID

16586096