(Q36450288)

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Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.

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28 February 2020

Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells (English)

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28 February 2020

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28 February 2020

author name string

Hye-Sook Seo

1

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28 February 2020

Jae Kyung Jo

2

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28 February 2020

Jin Mo Ku

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28 February 2020

Han-Seok Choi

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28 February 2020

Youn Kyung Choi

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28 February 2020

Hyo In Kim

7

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28 February 2020

Soo-Yeon Kang

8

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28 February 2020

Kang Min Lee

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28 February 2020

Koong Won Nam

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28 February 2020

Namkyu Park

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28 February 2020

Bo-Hyoung Jang

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28 February 2020

Yong Cheol Shin

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28 February 2020

Seong-Gyu Ko

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28 February 2020

publication date

23 October 2015

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28 February 2020

Bioscience Reports

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28 February 2020

35

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28 February 2020

6

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28 February 2020

copyright license

Creative Commons Attribution 3.0 Unported

25 July 2019

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April 2022 Public Data File from Crossref

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0 references

A systematic review of dual targeting in HER2-positive breast cancer

1 reference

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30 September 2017

Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway

1 reference

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30 September 2017

Caspase functions in cell death and disease

1 reference

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30 September 2017

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

1 reference

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30 September 2017

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo

1 reference

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30 September 2017

Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29).

1 reference

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30 September 2017

Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α-negative breast cells

1 reference

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30 September 2017

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

1 reference

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30 September 2017

Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Apigenin: a promising molecule for cancer prevention

1 reference

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30 September 2017

Mechanisms of trastuzumab resistance in breast cancer

1 reference

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30 September 2017

Role of biologic therapy and chemotherapy in hormone receptor- and HER2-positive breast cancer

1 reference

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30 September 2017

Her2-positive breast cancer: herceptin and beyond.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT.

1 reference

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30 September 2017

STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

1 reference

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30 September 2017

Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Implications of phytoestrogen intake for breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Apoptosis: a review of programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Trastuzumab and breast cancer: developments and current status

1 reference

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30 September 2017

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

1 reference

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30 September 2017

Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors

1 reference

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30 September 2017

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

1 reference

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30 September 2017

Targeting STAT3 affects melanoma on multiple fronts

1 reference

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30 September 2017

Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer

1 reference

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30 September 2017

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

1 reference

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30 September 2017

Flavonoids and breast cancer risk in Italy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Development of Herceptin resistance in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Biologic and therapeutic role of HER2 in cancer

1 reference

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30 September 2017

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

1 reference

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30 September 2017

Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).

1 reference

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30 September 2017

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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30 September 2017

Mechanisms of p53-dependent apoptosis

1 reference

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30 September 2017

p53-dependent apoptosis pathways.

1 reference

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30 September 2017

Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity

1 reference

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30 September 2017

Cell death induced by the Fas/Fas ligand pathway and its role in pathology

1 reference

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30 September 2017

Mitochondria and apoptosis

1 reference

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30 September 2017

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Occupational exposure and 25-year incidence rate of non-specific lung disease: the Zutphen Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

30 September 2017

Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation

1 reference

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28 June 2018

Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

28 June 2018

Flavonoids and ovarian cancer risk: A case-control study in Italy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Activation of stat3 in human melanoma promotes brain metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Dietary flavonoids and cancer risk in the Zutphen elderly study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Study of antioxidant effect of apigenin, luteolin and quercetin by DNA protective method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 September 2018

Targeting breast cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4708008

21 October 2018

Identifiers

10.1042/BSR20150165

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Europe PubMed Central

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28 February 2020

1 reference

Europe PubMed Central

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28 February 2020

1 reference

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28 February 2020

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