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A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.
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Europe PubMed Central
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3516478
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21 February 2020
title
A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling
(English)
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Europe PubMed Central
PMCID
3516478
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
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21 February 2020
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Eukaryotic translation initiation factor 3 subunit f1 Dmel_CG9769
1 reference
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GOA release 2020-03-11
Eukaryotic translation initiation factor 3 subunit h Dmel_CG9124
1 reference
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GOA release 2020-03-11
author
Ying Su
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3
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Europe PubMed Central
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3516478
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21 February 2020
author name string
Junzheng Zhang
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1
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Europe PubMed Central
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3516478
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21 February 2020
Min Liu
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2
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Europe PubMed Central
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3516478
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
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21 February 2020
Juan Du
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4
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Europe PubMed Central
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
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21 February 2020
Alan Jian Zhu
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5
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Europe PubMed Central
PMCID
3516478
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21 February 2020
publication date
1 December 2012
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21 February 2020
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21 February 2020
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2
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21 February 2020
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12
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21 February 2020
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1563-1575
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21 February 2020
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Notch signalling: a simple pathway becomes complex
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The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
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The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila
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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
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30 September 2017
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
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30 September 2017
Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling
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A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets
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30 September 2017
Protein degradation: four E3s for the notch pathway
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30 September 2017
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.
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30 September 2017
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
The drosophila melanogaster genome: translation factors and RNA binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Notch signaling: cell fate control and signal integration in development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
30 September 2017
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
The emergence of sense organs in the wing disc of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
The fat facets gene is required for Drosophila eye and embryo development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
28 June 2018
The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Characterization of big bang, a novel gene encoding for PDZ domain-containing proteins that are dynamically expressed throughout Drosophila development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
The interplay between DSL proteins and ubiquitin ligases in Notch signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Neuralized functions as an E3 ubiquitin ligase during Drosophila development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
A model Notch response element detects Suppressor of Hairless-dependent molecular switch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
21 September 2018
What Determines the Specificity and Outcomes of Ubiquitin Signaling?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516478
retrieved
4 December 2018
Proteolysis: from the lysosome to ubiquitin and the proteasome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23275879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1534/G3.112.003780
1 reference
stated in
Europe PubMed Central
PMCID
3516478
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
PMCID
3516478
1 reference
stated in
Europe PubMed Central
PMCID
3516478
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
PubMed ID
23275879
1 reference
stated in
Europe PubMed Central
PMCID
3516478
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23275879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
ResearchGate publication ID
234012486
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