(Q37804446)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

The multiple facets of ubiquitination in the regulation of notch signaling pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

main subject

protein ubiquitination

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Stéphanie Le Bras

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Nicolas Loyer

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

publication date

29 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

149-161

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21029288%20AND%20SRC:MED&resulttype=core&format=json

The canonical Notch signaling pathway: unfolding the activation mechanism

15 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Notch signalling: a simple pathway becomes complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The many facets of Notch ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of Notch signalling by endocytosis and endosomal sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Proteasome-independent functions of ubiquitin in endocytosis and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

An obligatory role of mind bomb-1 in notch signaling of mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mind bomb-2 is an E3 ligase for Notch ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Neuralized promotes basal to apical transcytosis of delta in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Neuralized functions cell autonomously to regulate Drosophila sense organ development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Genome engineering-based analysis of Bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of Notch signalling by non-visual beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Down-regulation of Notch target gene expression by Suppressor of deltex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Structural basis for autoinhibition of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Endocytic internalization routes required for delta/notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The adhesion force of Notch with Delta and the rate of Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Endocytic control of epithelial polarity and proliferation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2010.01126.X