(Q36452404)

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Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

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24 January 2020

Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach (English)

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24 January 2020

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cannabinoid receptor

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24 January 2020

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24 January 2020

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24 January 2020

Daniele Bolognini

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Daniele Bolognini

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24 January 2020

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Claudia Mugnaini

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24 January 2020

Stefania Nocerino

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24 January 2020

Valentina Pedani

3

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24 January 2020

Serena Pasquini

4

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24 January 2020

Andrea Tafi

5

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24 January 2020

Maria De Chiaro

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24 January 2020

Luca Bellucci

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24 January 2020

Francesca Guida

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24 January 2020

Stefania Dragoni

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24 January 2020

Alessia Ligresti

12

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24 January 2020

Avraham Rosenberg

13

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24 January 2020

Maria Grazia Cascio

15

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24 January 2020

Ruin Moaddel

17

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24 January 2020

Sabatino Maione

18

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24 January 2020

Vincenzo Di Marzo

19

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24 January 2020

Federico Corelli

20

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24 January 2020

publication date

2 March 2012

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24 January 2020

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24 January 2020

7

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24 January 2020

5

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24 January 2020

920-934

1 reference

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PMC publication ID

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24 January 2020

AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Synopsis of some recent tactical application of bioisosteres in drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain

1 reference

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30 September 2017

A medicinal chemist's guide to molecular interactions

1 reference

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30 September 2017

Simultaneous optimization of potency, selectivity and physicochemical properties for cannabinoid CB(2) ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Endocannabinoid system modulation in cancer biology and therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoids in the treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

1 reference

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30 September 2017

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Antagonists of the P2X(7) receptor. From lead identification to drug development.

1 reference

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30 September 2017

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoids for cancer treatment: progress and promise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

CB2 receptor-mediated migration of immune cells: it can go either way

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoid receptors in acute and chronic complications of atherosclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoids and neuroprotection in basal ganglia disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

High throughput solubility measurement in drug discovery and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Biological assay challenges from compound solubility: strategies for bioassay optimization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Pharmacological actions of cannabinoids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Role of pharmacologically active metabolites in drug discovery and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoids: potential anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Cannabinoid receptors and their ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

The formalin test: scoring properties of the first and second phases of the pain response in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Molecular characterization of a peripheral receptor for cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

30 September 2017

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

28 June 2018

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

28 June 2018

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516921

28 June 2018

A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Synthesis of steroidal diacyl hydrazines and their 1,3,4-oxadiazole derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Sterically biased 3,3-sigmatropic rearrangement of chiral allylic azides: application to the total syntheses of alkaloids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

General atomic and molecular electronic structure system

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

21 January 2018

Pair interaction energy decomposition analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22383251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoids and multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22383251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

7 January 2021

based on heuristic

inferred from DOI database lookup

Rationale and benefit of using high throughput solubility screens in drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

7 January 2021

based on heuristic

inferred from DOI database lookup

A new energy decomposition scheme for molecular interactions within the Hartree-Fock approximation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100573

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1002/CMDC.201100573

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22383251%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22383251%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22383251%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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