(Q36456760)

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Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design

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Europe PubMed Central

PMC publication ID

14 August 2017

Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

vaccine engineering

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Brian M Baker

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Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Oleg Y Borbulevych

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Tiffany K Baxter

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Zhiya Yu

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Nicholas P Restifo

4

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Europe PubMed Central

PMC publication ID

14 August 2017

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publication date

1 April 2005

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Europe PubMed Central

PMC publication ID

14 August 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

14 August 2017

174

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Europe PubMed Central

PMC publication ID

14 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

4812-4820

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

T cell cross-reactivity and conformational changes during TCR engagement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2241749

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Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance

1 reference

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A listing of human tumor antigens recognized by T cells: March 2004 update

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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ARP/wARP and automatic interpretation of protein electron density maps

1 reference

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Tax and M1 peptide/HLA-A2-specific Fabs and T cell receptors recognize nonidentical structural features on peptide/HLA-A2 complexes

1 reference

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Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma

1 reference

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Modification of a tumor-derived peptide at an HLA-A2 anchor residue can alter the conformation of the MHC-peptide complex: probing with TCR-like recombinant antibodies.

1 reference

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MHC allele-specific molecular features determine peptide/HLA-A2 conformations that are recognized by HLA-A2-restricted T cell receptors

1 reference

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Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes

1 reference

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High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene

1 reference

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Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts

1 reference

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Structural and functional consequences of altering a peptide MHC anchor residue

1 reference

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The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site

1 reference

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The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes

1 reference

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Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide

1 reference

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

1 reference

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Recombinant virus vaccination against "self" antigens using anchor-fixed immunogens

1 reference

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

1 reference

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Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry

1 reference

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Heteroclitic immunization induces tumor immunity

1 reference

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Prediction of binding energetics from structure using empirical parameterization

1 reference

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Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2241749

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Homology modeling, model and software evaluation: three related resources

1 reference

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Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1 reference

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

1 reference

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Antagonist HIV-1 Gag peptides induce structural changes in HLA B8

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2241749

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Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

1 reference

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1 reference

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HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides

1 reference

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An allosteric mechanism controls antigen presentation by the H-2K(b) complex

1 reference

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Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

1 reference

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Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition

1 reference

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MHC recognition by hapten-specific HLA-A2-restricted CD8+ CTL.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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based on heuristic

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Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15814707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/15814707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15814707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the fine specificity of gp100(209-217)-reactive T cells in patients following vaccination with a peptide modified at an HLA-A2.1 anchor residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/15814707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.174.8.4812

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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