(Q36460835)

14 August 2017

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title

Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients (English)

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14 August 2017

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Hypericum perforatum

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Manfred Schubert-Zsilavecz

inferred from title

author

series ordinal

2

object named as

Manfred Schubert-Zsilavecz

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14 August 2017

Mario Wurglics

1

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14 August 2017

publication date

1 January 2006

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Clinical Pharmacokinetics

14 August 2017

published in

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14 August 2017

volume

45

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14 August 2017

issue

5

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14 August 2017

page(s)

449-468

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https://scigraph.springernature.com/pub.10.2165/00003088-200645050-00002

14 August 2017

exact match

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cites work

ABC of mental health. Depression

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Effects of St. John's wort on irinotecan metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence

21 January 2018

2 references

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

21 January 2018

12 December 2020

Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200645050-00002

Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin

21 January 2018

1 reference

12 December 2020

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

1 reference

12 December 2020

Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products

1 reference

12 December 2020

Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers

1 reference

12 December 2020

Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.

1 reference

12 December 2020

Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media

1 reference

12 December 2020

Adrenal gland volume in major depression: relationship to basal and stimulated pituitary-adrenal cortical axis function.

1 reference

12 December 2020

The interaction between St John's wort and an oral contraceptive

1 reference

12 December 2020

[Neuroendocrinologic and endocrinologic research in depressive patients]

1 reference

12 December 2020

Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man

1 reference

12 December 2020

Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.).

1 reference

12 December 2020

Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test

1 reference

12 December 2020

Inhibition of vesicular uptake of monoamines by hyperforin

1 reference

12 December 2020

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

1 reference

12 December 2020

Potential metabolic interaction between St. John's wort and theophylline

1 reference

12 December 2020

Determination of rutin in human plasma by high-performance liquid chromatography utilizing solid-phase extraction and ultraviolet detection.

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12 December 2020

Hyperforin as a possible antidepressant component of hypericum extracts

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12 December 2020

Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.

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12 December 2020

Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test

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12 December 2020

Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin

1 reference

12 December 2020

Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus

1 reference

12 December 2020

Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet

1 reference

12 December 2020

St John's wort for depression: meta-analysis of randomised controlled trials

1 reference

12 December 2020

Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry

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12 December 2020

In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract

1 reference

12 December 2020

Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane

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12 December 2020

Inhibition of MAO and COMT by hypericum extracts and hypericin.

1 reference

12 December 2020

Drug interactions with St John's wort : mechanisms and clinical implications

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways

1 reference

12 December 2020

Vasoactive properties of procyanidins from Hypericum perforatum L. in isolated porcine coronary arteries

1 reference

12 December 2020

Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L

1 reference

12 December 2020

Depressive disorders in Europe: prevalence figures from the ODIN study

1 reference

12 December 2020

Antioxidant flavonols and coronary heart disease risk

1 reference

12 December 2020

Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial

1 reference

12 December 2020

Bioavailability of rutin and quercetin in rats

1 reference

12 December 2020

Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine

1 reference

12 December 2020

Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection

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12 December 2020

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

1 reference

12 December 2020

Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity

1 reference

12 December 2020

St John's Wort supplements endanger the success of organ transplantation

1 reference

12 December 2020

Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain

1 reference

12 December 2020

Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement

1 reference

12 December 2020

The role of multidrug transporters in drug availability, metabolism and toxicity

1 reference

12 December 2020

Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans.

1 reference

12 December 2020

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

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12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

12 December 2020

Second thoughts about safety of St John's wort

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12 December 2020

Acute heart transplant rejection due to Saint John's wort

1 reference

12 December 2020

Hypericin in cancer treatment: more light on the way.

1 reference

12 December 2020

Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

1 reference

12 December 2020

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy

1 reference

12 December 2020

St John's wort, a herbal antidepressant, activates the steroid X receptor.

1 reference

12 December 2020

Treatment of acute depression.

1 reference

12 December 2020

The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors

1 reference

12 December 2020

In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

1 reference

12 December 2020

A study of the antidepressant activity of Hypericum perforatum on animal models

1 reference

12 December 2020

The economic impact of depression in a workplace.

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12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

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12 December 2020

Biologically active and other chemical constituents of the herb of Hypericum perforatum L.

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12 December 2020

Hypericum perforatum--a review of clinical studies

1 reference

12 December 2020

Hyperforin modifies neuronal membrane properties in vivo

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12 December 2020

Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers

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12 December 2020

Hyperforin--antidepressant activity by a novel mechanism of action

1 reference

12 December 2020

The effects of extracts from St. John's Wort and Kava Kava on brain neurotransmitter levels in the mouse

1 reference

12 December 2020

Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat.

1 reference

12 December 2020

Inhibition of monoamine oxidase by hypericin.

1 reference

12 December 2020

Depression in the community: the first pan-European study DEPRES (Depression Research in European Society)

1 reference

12 December 2020

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

1 reference

12 December 2020

Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment

1 reference

12 December 2020

Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection

1 reference

12 December 2020

Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats

1 reference

12 December 2020

Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers

1 reference

12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

1 reference

12 December 2020

Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts

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12 December 2020

Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates

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12 December 2020

Pharmacokinetics and bioavailability of the flavonol quercetin in humans.

1 reference

12 December 2020

In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine

1 reference

12 December 2020

Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers

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12 December 2020

Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test

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12 December 2020

Flavonoids of St. John's Wort reduce HPA axis function in the rat.

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12 December 2020

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

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12 December 2020

Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum.

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12 December 2020

Herb-drug interactions

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12 December 2020

Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme

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12 December 2020

Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort

1 reference

12 December 2020

Interaction of St John's wort with low‐dose oral contraceptive therapy: a randomized controlled trial

1 reference

12 December 2020

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

1 reference

12 December 2020

A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography

1 reference

12 December 2020

Human P450 metabolism of warfarin

1 reference

12 December 2020

Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity.

1 reference

12 December 2020

The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man

1 reference

12 December 2020

In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters

1 reference

12 December 2020

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

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12 December 2020

In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives

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12 December 2020

Animal model of depression

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12 December 2020

Batch-to-batch reproducibility of St. John's wort preparations

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12 December 2020

Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection

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12 December 2020

Cost of depression among adults in England in 2000.

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12 December 2020

Pharmacokinetics and bioavailability of quercetin glycosides in humans

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12 December 2020

Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry

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12 December 2020

Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation

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12 December 2020

Pharmacology of antidepressants

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12 December 2020

Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism

1 reference

12 December 2020

Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception

1 reference

12 December 2020

Transport of amentoflavone across the blood-brain barrier in vitro

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12 December 2020

Effectiveness of St John's wort in major depression: a randomized controlled trial

1 reference

12 December 2020

10.2165/00003088-200645050-00002

Identifiers

DOI

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Dimensions Publication ID

14 August 2017

1035343744

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