(Q36461897)

14 August 2017

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title

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. (English)

1 reference

14 August 2017

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Asish K Saha

2

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Neil B Ruderman

object named as

Neil B Ruderman

series ordinal

1

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publication date

1 February 2006

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14 August 2017

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14 August 2017

volume

14 Suppl 1

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14 August 2017

page(s)

25S-33S

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Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Exercise and insulin signaling: a historical perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

Cellular mechanisms of insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

Banting lecture 1988. Role of insulin resistance in human disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

Cardiovascular morbidity and mortality associated with the metabolic syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

Increasing prevalence of the metabolic syndrome among u.s. Adults.

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Insulin resistance of denervated rat muscle: a model for impaired receptor-function coupling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Sarcomere dynamics during isotonic velocity transients in single frog muscle fibers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Increased protein kinase C theta in skeletal muscle of diabetic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Management of cellular energy by the AMP-activated protein kinase system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP-activated protein kinase, super metabolic regulator

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Regulation of fasted blood glucose by resistin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Interleukin-6-deficient mice develop mature-onset obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Malonyl coenzyme A and adiposity in the dahl salt-sensitive rat: Effects of pioglitazone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Rapid transformation of white adipocytes into fat-oxidizing machines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP-activated protein kinase plays a role in the control of food intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

AMPK, the metabolic syndrome and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

Long-term AICAR administration and exercise prevents diabetes in ZDF rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.279

31 March 2020

Identifiers

DOI

10.1038/OBY.2006.279

1 reference

14 August 2017

1 reference